نتایج جستجو برای: cmv enhancer

تعداد نتایج: 28001  

Human cytomegalovirus (CMV) remains the most common infection affecting organ transplant recipients. Despite advances in the prophylaxis and acute treatment of CMV, it remains an important pathogen affecting the short- and long-term clinical outcome of solid organ transplant recipient. The emergence of CMV resistance in a patient reduces the clinical efficacy of antiviral therapy, complicates t...

Journal: :Mechanisms of Development 2009
Simon Harding Jamie Davies Jane Armstrong Jane Brennan Sue Lloyd-MacGlip Derek Houghton Mehran Sharghi Xingjun Pi Ying Cheng Bruce Aronow Sean Grimmond Peter Koopman James Lessard Melissa Little Andy McMahon Cathy Mendelsohn Steve Potter Michelle Southard-Smith Duncan Davidson

We have previously shown that lentiviral vectors can be used to generate transgenic chickens efficiently and that expression of introduced transgenes is not silenced on transmission through the germline. Transgene expression can be targeted in the predicted tissue-restricted manner, for example: muscle-specific expression is restricted to skeletal muscle using the rat myosin light chain 3 gene ...

2014
Mariati Esther YC Koh Jessna HM Yeo Steven CL Ho Yuansheng Yang

M high gene expression level during long-term culture is critical when producing therapeutic recombinant proteins using mammalian cells. Transcriptional silencing of promoters, most likely due to epigenetic events such as DNA methylation and histone modifications, is one of the major mechanisms causing production instability. Previous studies demonstrated that the core CpG island element (IE) f...

Journal: :Blood 2003
David Dingli Rosa Maria Diaz Elizabeth R Bergert Michael K O'Connor John C Morris Stephen J Russell

Multiple myeloma is a disseminated neoplasm of terminally differentiated plasma cells that is incurable with currently available therapies. Although the disease is radiosensitive, external beam radiation leads to significant toxicity due to sensitive end-organ damage. Thus, genetic approaches for therapy are required. We hypothesized that the incorporation of immunoglobulin promoter and enhance...

حاتمی, حسین, شهابی, مجید, صفابخش, حمید رضا, طهرانیان, بهناز, طهرانیان, فرحناز, کرمی, غریب,

Background & Objectives: Prevalence of cytomegalovirus (CMV) infection varies is highly prevalent in different societies. CMV infection in susceptible patients is associated with serious morbidity and a high mortality and is a matter of concern for blood bank professionals and blood transfusion recipients, especially in cases of transfusions to neonates and immunocompromised patients. Thus, the...

ژورنال: :فصلنامه پژوهشی خون 0
فروغ اعظم طرآبادی f.a. tarabadi مرکز تحقیقات سازمان انتقال خون ایران دکتر ژولیت قالدی j. ghaledi مرکز تحقیقات سازمان انتقال خون ایرانسازمان اصلی تایید شده: سازمان انتقال خون ایران (blood transfusion research center) دکتر مژگان شایگان m. shaiegan مرکز تحقیقات سازمان انتقال خون ایرانسازمان اصلی تایید شده: سازمان انتقال خون ایران (blood transfusion research center) دکتر غلامرضا بابایی gh.r. babaee مرکز تحقیقات سازمان انتقال خون ایرانسازمان اصلی تایید شده: سازمان انتقال خون ایران (blood transfusion research center)

چکید ه   سابقه و هدف   ویروس سایتومگال انسانی یک ویروس dna دار با اندازه تقریبی200 نانومتر متعلق به خانواده هرپس ویروس ها می باشد. عفونت با cmv در بیماران دچار نقص ایمنی، دریافت کنندگان پیوند، بیماران مبتلا به ایدز، بیماران تحت درمان با عوامل سرکوب کننده ایمنی و جنین درحال رشد می تواند منجربه بیماری لوکالیزه یا منتشر شود. بیماران درمعرض خطر هردو عفونت اولیه و فعالیت مجدد عفونت نهفته می باشند. c...

2011
Hannah H Chen Ryan Cawood Yasser El-Sherbini Laura Purdie Miriam Bazan-Peregrino Leonard W Seymour Robert C Carlisle

The endothelium imposes a structural barrier to the extravasation of systemically delivered oncolytic adenovirus (Ad). Here, we introduced a transendothelial route of delivery in order to increase tumor accumulation of virus particles (vp) beyond that resulting from convection-dependent extravasation alone. This was achieved by engineering an Ad encoding a syncytium-forming protein, gibbon ape ...

2017
Sae-Mi Lee Yae-Jean Kim Keon Hee Yoo Ki Woong Sung Hong Hoe Koo Eun-Suk Kang

Cytomegalovirus (CMV) is a well-established cause of morbidity and mortality in pediatric recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). CD8⁺ T-cells are important for controlling CMV infection. We conducted a prospective pilot study to investigate the clinical utility of measuring the CMV-specific T-cell immune response using the QuantiFERON-CMV assay (QF-CMV) in...

Journal: :The Journal of infectious diseases 2005
Corine Bronke Nanette M Palmer Christine A Jansen Geertje H A Westerlaken Abeltje M Polstra Peter Reiss Margreet Bakker Frank Miedema Kiki Tesselaar Debbie van Baarle

BACKGROUND Since cytomegalovirus (CMV) infection can cause serious clinical complications in immunocompromised individuals, we assessed cellular immune requirements for protection against CMV end-organ disease (CMV-EOD) in human immunodeficiency virus type 1 (HIV-1) infection. METHODS Longitudinal samples from HIV-1-infected patients in the Amsterdam cohort were analyzed. Dynamics of CMV-spec...

Journal: :Frontiers in ophthalmology 2023

Purpose We hereby describe a case of persistent cytomegalovirus (CMV) viremia and retinitis following allogeneic hematopoietic cell transplantation (HCT) that was successfully treated with infusion CMV-specific cytotoxic T lymphocytes (CTL) despite previous treatment Epstein Bar Virus (EBV) -specific CTL, which occurred 5 months earlier. Observations Following several anti- viral medication tri...

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