نتایج جستجو برای: clozapine
تعداد نتایج: 3536 فیلتر نتایج به سال:
We thank Drs J. Finsterer and S. Zarrouk-Mahjoub [1] for their comments regarding our report [2] on the beneficial effects of low dose clozapine for management of psychotic symptoms in a patient with neurogenic ataxia-retinitis pigmentosa (NARP mutation, m.8993TNC, maternally inherited from asymptomatic carrier mother). We agree that clozapine has many side effects, some of them being potential...
The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT(3) receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT(3) receptors of various species. However, the structural requirements of the respective binding site for clozapine remain to be determined. Differences in the primary sequences within the 5-HT(3A) recep...
tolerance since the start of treatment. Nefopam was also introduced for the management of hemorrhoid pain as needed, at 20 mg/d (po). After an additional 35 days of treatment with clozapine at 350 mg/d, one night the patient had hematemesis and diffuse abdominal pain. The next morning, she experienced vomiting and complained of epigastric pain. The patient was treated with domperidone (30 mg/d)...
INTRODUCTION Metabolic syndrome is an important side effect associated with clozapine. It has been hypothesized that weight gain contributes to the development of metabolic syndrome, but a direct diabetogenic effect has also been suggested. We conducted an 8-year cohort study to determine the association between weight gain and metabolic parameters among schizophrenic patients taking clozapine....
s | 51 PM415 Clozapine-induced anemia and thrombocytosis Hanson Park, So Yeon Jeon St. Andrew’s Hospital, Republic of Korea Abstract Objective of the study: Clozapine is one of well-known antipsychotics which causes hematologic adverse effects, specifically neutropenia and agranulocytosis (1–3% of patients). We found a rare case of thrombocytosis and anemia after the re-administration of clozap...
s | 51 PM415 Clozapine-induced anemia and thrombocytosis Hanson Park, So Yeon Jeon St. Andrew’s Hospital, Republic of Korea Abstract Objective of the study: Clozapine is one of well-known antipsychotics which causes hematologic adverse effects, specifically neutropenia and agranulocytosis (1–3% of patients). We found a rare case of thrombocytosis and anemia after the re-administration of clozap...
S 16924 antagonized locomotion provoked by dizocilpine and cocaine, reduced conditioned avoidance responses and blocked climbing elicited by apomorphine, models predictive of control of the positive symptoms of schizophrenia: its median inhibitory dose (ID)50 was 0.96 mg/kg, s.c. vs. 1.91 for clozapine and 0.05 for haloperidol. Rotation elicited in unilateral, substantia nigra-lesioned rats by ...
INTRODUCTION Clozapine is the preferred antipsychotic for treatment-resistant schizophrenia, but has significant adverse effects, including gastrointestinal hypomotility or 'slow gut', which may result in severe constipation, ileus, bowel obstruction, and even death. These gastrointestinal effects remain inadequately recognized. METHODS We reviewed all reports of serious clozapine-induced gas...
BACKGROUND To date there has been no large-scale international study that examined the use of clozapine in older patients with schizophrenia. This study examined the use of clozapine and its demographic and clinical correlates in older patients with schizophrenia in East Asia during the period between 2001 and 2009. METHOD Information on 1,157 hospitalized patients with schizophrenia aged 50 ...
BACKGROUND Atypical antipsychotic agents (AAP) alleviate the symptoms of severe mental health disorders, such as schizophrenia, by antagonizing dopamine and serotonin receptors. Recently, AAP have also been shown to exhibit immunomodulatory properties in the central nervous system (CNS). OBJECTIVE Building on research which demonstrated the ability of the AAP risperidone and clozapine to modi...
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