A 2-year-old male red fox (Vulpes vulpes) was presented for generalised tonic-clonic seizures, blindness, compulsive circling and behavioural changes that occurred since the animal 2 months old. Neurological examination indicated a diffuse forebrain lesion. On magnetic resonance imaging of brain, severe dilation both lateral ventricles identified. Congenital hydrocephalus suspected treated with...

We present a case of tuberculous (TB) meningitis in nonimmunocompromised immigrant worker who initially presented with headache and later with generalized tonic clonic seizures and disseminated tuberculosis.

Hypothalamic hamartomas are congenital malformations: consisting of disorganized, mature, neuronal elements in proportions, similar to that of normal tissue. The clinical presentation may include any combination of the following: asymptomatic, precocious puberty, behavioral disturbances and various types of seizures. The seizure pattern usually consists of laughing (gelastic seizures) beginning...

Objective Studies have demonstrated the utility of closed-loop neuromodulation in treating focal onset seizures. There is an utmost need of neurostimulation therapy for generalized tonic-clonic seizures. The study goals are to map the thalamocortical network dynamics during the generalized convulsive seizures and identify targets for reliable seizure detection. Methods Local field potentials ...

Abstract Background Dravet syndrome (DS) is a severe epileptic encephalopathy in children dominated by polymorphic seizures. Focal cortical myoclonus indicated on conventional electroencephalogram (EEG) was rarely observed DS. Case presentation The child, boy, thirteen months old, suffered from clonic seizures during bathing at two old. Later he recurrent afebrile or febrile generalized tonic–c...

UNLABELLED Seizures have been reported with tramadol monotherapy in animal and human studies, both at recommended and high doses. After tramadol abuse or overdose, neurotoxicity is speculated to be related to the reuptake inhibition of serotonin and norepinephrine, rather than its opioid effects. THE AIM OF THIS STUDY is to show three unusual cases of seizures provoked by tramadol. CASE REPOR...

creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. creatine supplements have shown beneficial effects on neurological disorders including parkinson's disease, huntington's disease, amyotrophic lateral sclerosis, alzheimer's disease and stroke. however, the potential benefits of creatine for pati...

After generalized or partial seizures, transient lesions may appear on magnetic resonance (MR) images. The mechanisms of MR changes might be a defect in cerebral autoregulation and blood-brain permeability. We report a patient with partial and secondary generalized tonic-clonic seizures. After her first seizure which was generalized tonic-clonic in nature, we detected multiple high signal inten...

Neuroactive steroids represent potential antiepileptic drugs. We tested a newly synthesized analogue of allopregnanolone 3alpha-hydroxy-21xi,22-oxido-21-homo-5alpha-pregnan-20-on (HOHP) against two types of pentylenetetrazol-induced seizures (100 mg/kg s.c.) in 12- and 25-day-old rats. Ganaxolone, a neuroactive steroid in clinical trials, served as a reference drug. Pretreatment with either ste...