نتایج جستجو برای: click chemistry
تعداد نتایج: 118439 فیلتر نتایج به سال:
Lanthanide complexes of azidophenacyl DO3A are effective substrates for click reactions with ethyne derivatives, giving rise to aryl triazole appended lanthanide complexes, in which the aryl triazole acts as an effective sensitising chromophore for lanthanide luminescence. They also undergo click chemistry with propargylDO3A derivatives, giving rise to heterometallic complexes.
The alkyne-azide cycloaddition, popularly known as the "click" reaction, has been extensively exploited in molecule/macromolecule build-up, and has offered tremendous potential in the design of nanomaterials for applications in a diverse range of disciplines, including biology. Some advantageous characteristics of this coupling include high efficiency, and adaptability to the environment in whi...
The CuAAC reaction (click chemistry) has been used in conjunction with solid-phase synthesis to produce catalytically active hairpin ribozymes around 100 nucleotides in length. Cross-strand ligation through neighboring nucleobases was successful in covalently linking presynthesized RNA strands with high efficiency (trans-ligation). In an alternative strategy, intrastrand click ligation was empl...
A series of novel glycol-clusters containing sulfonated N-acetyl-D-glucosamine (GlcNAc) have been synthesized using click chemistry. Three dendrimers with aromatic dendrons were synthesized using chlorination, azidation and click chemistries. The resulting dendrimers were modified with azide-terminated sulfonated GlcNAc using click chemistry. The sulfonated dendrimers showed affinity for protei...
Esterification and click-chemistry were evaluated as surface modification treatments for TEMPO-oxidized nanocelluloses (TONC) using Polycaprolactone-diol (PCL) as modifying compound in order to improve the dispersion of nanofibers in organic media. These two grafting strategies were analyzed and compared. The first consists of grafting directly the PCL onto TONC, and was carried out by esterifi...
We describe the use of iterative in situ click chemistry to design an Akt-specific branched peptide triligand that is a drop-in replacement for monoclonal antibodies in multiple biochemical assays. Each peptide module in the branched structure makes unique contributions to affinity and/or specificity resulting in a 200 nM affinity ligand that efficiently immunoprecipitates Akt from cancer cell ...
چکیده هدف این پایاننامه تهیه مشتقات پیرول میباشد که از ترکیبات اساسی در شیمی دارویی، گسترش داروها و سنز محصولات طبیعی محسوب میشود. در اینجا سنتز پیرول به روش پال-نور در حلال آب به عنوان حلالی ارزان و سازگار با محیط زیست که در صنعت و آزمایشگاه استفاده میشود مورد مطالعه قرار گرفتهاست. بهترین شرایط واکنش با استفاده از al(ds)3به عنوان کاتالیست ترکیبی لویس اسید-سورفاکتانت (lasc) در حلال آب و...
Although the concept of click chemistry was proposed more than twenty years ago, research progress has emerged with great vitality, and this year's Nobel Prize in once again highlighted importance field chemistry. Click is a reaction which variety molecules are quickly reliably synthesized by piecing together small units. In particular, it emphasizes development new combinatorial methods based ...
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