The present paper is intended as a contribution to the specific chemistry of the naturally occurring hydroxyamino acids. Certain established differences in the chemistry of the acyl derivatives of amino and hydroxy groups have so far not been utilized in the study of hydroxyamino acids, and in particular no simple method for the preparation of their 0-acetyl derivatives has been developed. The ...

Despite the paramount importance of protein-nucleic acid interactions in different cellular processes, our understanding of such interactions at the atomistic level remains incomplete. We have used molecular dynamics (MD) simulations and 15 μs of sampling time to study the behavior of amino acids and amino-acid sidechain analogs in aqueous solutions of different mimetics of naturally occurring ...

The present paper is intended as a contribution to the specific chemistry of the naturally occurring hydroxyamino acids. Certain established differences in the chemistry of the acyl derivatives of amino and hydroxy groups have so far not been utilized in the study of hydroxyamino acids, and in particular no simple method for the preparation of their 0-acetyl derivatives has been developed. The ...

In this work we report the preparation of two metallamacrocyclic tetranuclear manganese(II) complexes, [L1(4)Mn4](ClO4)4 and [L2(4)Mn4](ClO4)4 where L1 and L2 are the anions of the heptadentate ligands 2-((2-(bis(pyridin-2-ylmethyl)amino)ethyl)(methyl)amino)acetic acid and 2-(benzyl(2-(bis(pyridin-2-ylmethyl)amino)ethyl)amino)acetic acid), respectively. The complexes have been fully characteriz...

Recently, Weiner and Hood (Science 190:987989, 1975) reported the use of an acid hydrolysis procedure in the study of the aspartic acid linkages of the soluble protein of the organic matrix of mollusk shells. Peptide bonds on both sides of aspartic acid residues have been shown to be particularly labile to hydrolysis by dilute acetic or hydrochloric acids (SCHULTZ et al, Biochemistry 1:694-698,...

1. The effect of an 18, 30 or 40 h fast on the rate of purine biosynthesis de novo as measured by the incorporation of [14C]formate into formylglycinamide ribonucleotide during azaserine block has been examined in the rat spleen. 2. There is a reproducible fall in the rate of purine biosynthesis de novo during fasting. Values at 40 h were approximately one-third of the values in the colony-fed ...

In this study, a new series of 6-amino-1,3-dimethyluracil derivative with 6-(3-substituted N-benzylidene)-1,3-dimethyl pyrimidine-2,4-dione-6-yl derivatives which were synthesized by using one pot synthesis. The reaction and different aromatic aldehyde in ethanol yielded Schiff bases (1-6). the subsequent step )1-6) 2-mercaptoacetic acid, 2-chloroacetic acid 2-amino acetic acidn Tetrahydrofuran...

The three coat proteins of foot-and-mouth disease virus type 0 can be separated in milligram amounts using a SE-cellulose ionic exchanger, both from each other and viral RNA not quantitatively precipitated by acetic acid. The amino acid composition of the separated proteins has been determined and a statistical method has been used to calculate, for each, the most probable number of amino acids...

Adaptation of cells to acetic acid requires a hitherto unknown number of proteins. Studies on the GPR1 gene and its encoded protein in the ascomycetous fungus Yarrowia lipolytica have revealed an involvement of this protein in the molecular processes of adaptation to acetic acid. Gpr1p belongs to a novel family of conserved proteins in prokaryotic and eukaryotic organisms that is characterized ...