Biologics manufacturing has seen many new developments in recent years. The industry is moving away from processing systems based on stainless steel (with cleaning and validation requirements) to single-use (sterilized, disposable plastics). This communication presents an overview of the current mixing technology landscape, requirements challenges driven by need for versatile biomanufacturing p...

Laser removal of particles from solid surfaces was investigated both theoretically and experimentally. A cleaning model was established for laser-induced removal of particles from solid surfaces by taking Van der Waals force, capillary force and cleaning force into account. Laser cleaning forces are induced by fast thermal expansion of particles and/or solid surfaces irradiated by laser for dry...

When a fluticasone propionate (FP) diskhaler is used to administer inhaled corticosteroid, it has been reported that there is considerable drug residue remaining in the diskhaler after use. The internal structure of the diskhaler is complex, and it is possible that sufficient cleaning of the device is not achieved using the attached brush. In this study, the diskhaler cleaning method was examin...

Reprocessing comprises three steps: cleaning, disinfection and-if required-sterilisation. While the extents of disinfection and of sterilisation are quantitatively defined, there are only imprecise (qualitative) definitions of cleaning. There are two main reasons for accurate cleaning. First organic and inorganic materials that remain on inner and outer surfaces will interfere with the efficacy...

This paper describes the experience gained in Sweden in connection with early phase-out of CFC-113 in the production engineering industry. It concentrates particularly on the phase-out of CFC-113 in the production of PCB assemblies, although parallel applications for cleaning of precision components, metal cleaning and : to some extent the phase-out of l,l,l-trichloroethane are also considered....

OBJECTIVE Most reusable biopsy forceps and all of the currently available single-use biopsy forceps do not have a port that allows fluid flow down the inner tubular shaft of the device. Reusable biopsy forceps are widely used and reprocessed in healthcare facilities, and single-use biopsy forceps are reprocessed either in-house (eg, in Canada and Japan) or by third-party reprocessors (eg, in th...

The aim is a cleaning robot which automatically cleans the outside of windows on a facade with vertical jambs and horizontal bars. The facade has to possess certain constructive properties. This "interface" enables the cleaning robot which is detachable from the building and portable to operate on any respectively designed facade on several buildings. A special cleaning-head keeps the water use...