In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with 5-(aryl)furfural derivatives. The compounds were evaluated for their in vitro antimicrobial effects on pathogenic bacteria and Candida species using microdilution and ATP luminescenc...

BACKGROUND AND THE PURPOSE OF THE STUDY Various compounds from natural and synthetic origins containing the 1,3-diarylpropenone structure have been reported to produce a variety of biological activities like anti-microbial, anti-inflammatory, vascular muscle relaxant, etc. A systematic analysis of the structural features responsible for anti-inflammatory activity and a possible mode of their ac...

A tandem rhodium-catalyzed Bamford-Stevens/Claisen rearrangement is presented. The tandem reaction uses Eschenmoser hydrazones for the in situ generation of non-carbonyl-stabilized diazo alkanes, which are presumably intercepted by Rh(II) catalysts to induce a 1,2-hydride migration. This sequence provides high levels of stereocontrol for the generation of simple acyclic (Z)-enol ethers. These e...

The title compound, C(15)H(14)O(2), was prepared from 4-methyl-hypnone and 5-methyl-furfural by Clasion-Schmidt condensation. All of the bond lengths and bond angles are in normal ranges. The dihedral angle formed by the benzene ring and furan ring is 5.31 (2).

The first total synthesis of polycyclic Stemona alkaloid maistemonine has been achieved. The efficient approach features a stereoselective intramolecular Schmidt reaction, a ketone-ester condensation, and a Reformatsky reaction. Additionally, another Stemona alkaloid stemonamide was divergently synthesized from a common intermediate.

Encouraged by the biological activities associated with chalcones and furo[3,2-c]pyridine, the present paper describes the synthesis, spectroscopic identification and antibacterial activity of furo[3,2-c]pyridine chalcone derivatives i.e. 8a-8g in a few high yielding steps from commercially available 2-Furaldehyde. Claisen Schmidt condensation of aldehyde 7 with various acetophenones (R = a-g) ...

Cervical cancer is the second leading cause of death in women. Many treatments currently provide toxic effects on normal cells. Therefore, alternative treatment using chalcone derivatives has potent anticancer properties that can help reduce side effects. Chalcone with halogen and methoxy groups ring B potentially inhibit This research aimed to synthesize halogen-substituted by a green chemistr...