نتایج جستجو برای: cladribine

تعداد نتایج: 689  

Journal: :Journal of the Chinese Medical Association : JCMA 2007
Yuan-Bin Yu Chun-Yi Li Chih-Cheng Chen Jie-Yu You Wing-Keung Chau Hui-Chi Hsu Jyh-Pyng Gau Po-Ming Chen Chao-Hung Ho

BACKGROUND Hairy cell leukemia (HCL) is a rare B-cell lymphoid malignancy that is characterized by the presence of hairy cells in the peripheral blood and bone marrow, pancytopenia and various degrees of splenomegaly. Very few reports have explored the clinicopathologic features and treatment outcome of HCL in Taiwan. METHODS Of 33 patients with malignant lymphoma who underwent splenectomy ov...

Journal: :Blood 2006
Farhad Ravandi Jeffrey L Jorgensen Susan M O'Brien Srdan Verstovsek Charles A Koller Stefan Faderl Francis J Giles Alessandra Ferrajoli William G Wierda Shirley Odinga Xuelin Huang Deborah A Thomas Emil J Freireich Dan Jones Michael J Keating Hagop M Kantarjian

Although the nucleoside analogs cladribine and pentostatin produce high response rates in patients with hairy cell leukemia (HCL), a significant number of patients eventually relapse. Several studies have demonstrated that patients with complete remission (CR) have a longer disease-free survival. Therefore, strategies to improve on the initial response to nucleoside analog therapy are likely to...

Journal: :Proceedings of the National Academy of Sciences 1996

فرات یزدی, محمد,

Introduction: HCL is a rare malignant condition that is curable if diagnosed early. HCL can present with reduced blood cells and splenomegaly which maybe misdiagnosed with other conditions. The aim of the present study was to determine the frequency of early clinical and laboratory findings as well as the response rate of patients to the standard treatment regimen of Cladribine. Methods: Th...

Journal: :international journal of hematology-oncology and stem cell research 0
reza safaei nodehi tehran university of medical sciences- hematology, oncology and bmt department behrouz gharib tehran university of medical sciences- hematology and oncology resident ramazaali sharifian tehran university of medical sciences- hematology, oncology and bmt department amirhossein emami tehran university of medical sciences- hematology, oncology and bmt department majid moghadaszadeh tabriz azad university of medical sciences-tabriz young researchers club sara sardashti tabriz university of medical sciences

introduction: acute leukemia covers a broad spectrum of hematological clonal diseases originating from the malignant transformation of stem cells. current chemotherapeutic methods result in an incomplete response to primary regimens in 30-40% of cases. methods: 20 patients who had been diagnosed with acute leukemia and who had displayed defined criteria in order to enter our study, were assesse...

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