Hepatoid adenocarcinoma is a special type of extrahepatic adenocarcinoma that morphologically mimics hepatocellular carcinoma (HCC). Clinical and immunohistochemical features of hepatoid adenocarcinoma are similar to those of HCC, such as elevated serum alpha-fetoprotein (AFP) level, immunoreactivity with AFP, polyclonal carcinoembryonic antigen (CEA), and alpha-1 antitrypsin. Because of these ...

OBJECTIVE Colorectal cancer (CRC) is among the most common malignancies worldwide. Understanding CRC prognosis at the initial diagnosis is very important for therapeutic strategy selection. This study was conducted to evaluate the prognostic value of preoperative serum carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125) for predicting 5-year r...

In this study, using the carcinoembryonic antigen (CEA)-expressing C15 murine colon carcinoma system in syngeneic C57BL/6 mice, we have evaluated the efficacy of bone marrow-derived dendritic cells (DCs) pulsed with the murine anti-idiotype antibody 3H1 as a tumor vaccine. Anti-idiotype 3H1 mimics a distinct and specific epitope of CEA and can generate anti-CEA immunity in mice, rabbits, monkey...

Two antigens cross-reactive with carc inoembryonic antigen (CEA) and distinct from the nonspecif ic cross-react ing antigen were identified in meconium by double immunodiffusion with a conventional goat ant i -CEA antiserum. These two antigens together competi t ively inhibited cross-react ing antibodies against them in CEA radioimmunoassay and contr ibuted to the measurement of meconium CEA le...

Two antigens cross-reactive with carc inoembryonic antigen (CEA) and distinct from the nonspecif ic cross-react ing antigen were identified in meconium by double immunodiffusion with a conventional goat ant i -CEA antiserum. These two antigens together competi t ively inhibited cross-react ing antibodies against them in CEA radioimmunoassay and contr ibuted to the measurement of meconium CEA le...

(51)Cr-prelabelled colon cancer cells (simulating 'circulating tumor cells', CTCs) were added to human peripheral blood and exposed to staurosporine (ST) to increase carcinoembryonic antigen (CEA) expression. CTCs were captured with immunomagnetic beads coated with Ber-EP4 monoclonal antibody, recognizing the common epithelial antigen present in the majority of cancer cells of epithelial origin...

PURPOSE To evaluate the efficacy of carcinoembryonic antigen (CEA) measurement for monitoring tumor progression during palliative chemotherapy in metastatic colorectal cancer. MATERIALS AND METHODS Forty-eight patients with initially unresectable metastatic colorectal cancer (n=26, 54.2%) or recurrent unresectable metastatic colorectal cancer (n=22, 45.8%) received FOLFOX-4 chemotherapy for p...

Background: Triple-negative breast cancer (TNBC) is determined by the absence of ERBB2, estrogen and progesterone receptors’ expression. Cancer vaccines, as the novel immunotherapy strategies, have emerged as promising tools   for treating the advanced stage of TNBC. The aim of this study was to evaluate Carcinoembryonic antigen (CEA), Metadherin (MTDH), and Mucin 1 (MUC-1) proteins as vaccine ...

Carcinoembryonic antigen (CEA) is a tumor marker that belongs to a family of closely related molecules with variable expression patterns. We have developed sets of oligonucleotide primers for the specific amplification of transcripts from individual CEA-family members using the reverse transcriptase/polymerase chain reaction (RT/PCR). Specific primer sets were designed for CEA, non-specific cro...