Immunohistochemistry should be applied in poorly differentiated cases to exclude chemosensitive and potentially curable tumors (i.e. lymphomas and germ cell tumors). If diagnosis is adenocarcinoma, immunostaining for prostate-specific antigen (PSA) in male patients and for estrogen and progesterone receptors in females with axillary node metastases is advisable to rule out hormone-sensitive tum...

AIMS To evaluate cytokeratin (CK) 7/20 expression patterns in salivary gland neoplasia. METHODS AND RESULTS Formalin-fixed paraffin embedded tissue from 153 salivary gland tumours were evaluated for CK7/20 immunoreactivity. The tumours included pleomorphic adenoma (n = 24), myoepithelioma (n = 9), papillary cystadenoma (n = 3), oncocytoma (n = 2), adenoid cystic carcinoma (n = 22), mucoepider...

We present a case of cytokeratin (CK) 20-positive large cell neuroendocrine carcinoma (LCNEC) presenting with multiple skin metastases as the primary manifestation. The patient was a 55-year-old man who presented with a one- month history of subcutaneous skin colored nodules of various sizes on his trunk. Pathologic examination of the skin revealed a nested and solid proliferation of large undi...

On histological examination, mitoses were easily found: 3/10 fields and there were multiple foci of necrosis. On immunohistochemistry, the tumor cells were positive for CD31 and negative for: cytokeratine AE1-AE3, CK7,CK5-6,CK20,EMA,P63,PSA,CDX2,PSO4S, chromogranine A,PS100,CD34,Actine, Desmine, Caldesmone, CD117,DOG1. Post Irradiation Pelvic Sarcoma 8 Years after Treatment for Adenocarcinoma f...

Symptomatic gastrointestinal metastasis from lung malignancy is rarely reported. In this report, we present a case of lung adenocarcinoma with acute abdominal pain from small bowel perforation. The patient underwent small bowel resection and the final diagnosis was metastatic adenocarcinoma originating from lung. Immunohistochemistry was positive for thyroid transcription factor-1 and cytokerat...

In this study, we examined histopathologically and immunohistochemically 24 cases of laterocervical lymph node metastases with unknown primary origin. For immunohistochemical study, we used a large panel of antibodies represented by CK7, CK19, CK20, CKAE1/AE3, CK34betaE12, TTF1, HBME-1, CEA, MUC5AC and EBV. In the cases studied tumors accompanied by seemingly primitive adenopathies were located...

Ayedin et al2 compared the immunohistochemical profile of this tumour with RCC and described that papillary cystadenomas are positive for cytokeratin AE1/AE3 and EMA, CK7 and negative for CK20 and RCC immunostain. Four of 5 cases were negative for CD10. This staining profile contrasts with that reported for clear cell RCC, which are typically negative for CK7 and are immunoreactive for RCC and ...

A lymph node metastatic cell line (UP-LN1) was established in vitro from a poorly-differentiated epithelial tumor, and characterized for immunobiological and molecular cytogenetic profiles. The morphology of UP-LN1 cells when grown as monolayers was unique in that, apart from typical colonies of adherent epithelial cells, many loosely attached round cell colonies emerged on and around the patch...