Rhp14 of Schizosaccharomyces pombe is homologous to human XPA and Saccharomyces cerevisiae Rad14, which act in nucleotide excision repair of DNA damages induced by ultraviolet light and chemical agents. Cells with disrupted rhp14 were highly sensitive to ultraviolet light, and epistasis analysis with swi10 (nucleotide excision repair) and rad2 (Uve1-dependent ultraviolet light damage repair pat...

Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira. The whole-genome sequence of L. interrogans serovar Copenhageni together with bioinformatics tools represent a great opportunity to search for novel antigen candidates that could be used as subunit vaccine against leptospirosis. We focused on six genes encoding for conserved hypothetical proteins predicted to be exported to ...

Intracellular delivery of functional macromolecules using peptide transduction domains (PTDs) is an exciting technology with both experimental and therapeutic applications. Recent data indicate that PTD-mediated transduction occurs via fluid-phase macropinocytosis involving an intracellular pH drop to approximately 5. Nitrilotriacetic acid (NTA)-coordinated metals avidly bind hexahistidine-tagg...

This article examines the Mu‘tazilite Qādī ‘Abd al-Jabbār’s views on the denotation of miracles according to his own particular methodology. Despite his acceptance of the celebrated method of the theologians in the denotation of miracles with respect to the authenticity of prophets, i.e., resorting to divine wisdom, Qādī ‘Abd al-Jabbār instead proposed the issue within the structure of conven...

Abu Ali Hossein Ebn Abdullah Ben Ali Ben Sinna entitled as Shayhk-o-Rayeis in the East and well known in the west by the name of Avicenna was born in a place called Afsharneh near the city of Bokhara in 980 AD but resided in the city of Balkh. He was five years old when his father took him to the city of Bokhara to study Holy Quran where his extraordinary memory became apparent and he memorized...

Abu Ali Hossein Ebn Abdullah Ben Ali Ben Sinna entitled as Shayhk-o-Rayeis in the East and well known in the west by the name of Avicenna was born in a place called Afsharneh near the city of Bokhara in 980 AD but resided in the city of Balkh. He was five years old when his father took him to the city of Bokhara to study Holy Quran where his extraordinary memory became apparent and he memorized...

When Jacob Bronowski died in 1974, we lost one of the great minds of the twentieth century. His was a mind which could originate and develop complex theories in mathematics, biology, economics, and philosophy; yet his widespread appeal was certainly due in some part to his ability to think on the spot and communicate his ideas in common terms. This posthumous volume, which transcribes a series ...