We reported previously that circularly permuted interIeukin-4 (IL4), composed of amino acids 38-129 of IL4 connected by a linker peptide GGNGG to amino acids 1-37, is preferable to native II ,4 for fusing to the amino terminus of truncated Pseudomonas exotoxin (PE) to make a recombinant toxin, because the new ligand-toxin junction results in im proved IL4 receptor (IL4R)-binding (R. J. Kreitman...

Background Calcium hydroxylapatite (CaHA, Radiesse®) is a biocompatible, injectable filler for facial soft-tissue augmentation that provides volume to tissues, followed by a process of neocollagenesis for improved skin quality. Objective To examine the effects of CaHA treatment on the molecular organization of collagen using a combination of picrosirius red staining and circularly polarized l...

We study the partially eponymous model of distributed computation, which simultaneously generalizes the anonymous and the eponymous models. In this model, processors have identities, which are neither necessarily all identical, nor necessarily unique; processors receive inputs and must reach outputs that respect a relation. We focus on the partially eponymous ring R, and we are interested in th...

The role that domain flexibility plays in the enzymatic activity of beta-lactamase from Staphylococcus aureus PC1 was investigated by producing two circularly permuted molecules. The C- and N-termini of the wild-type enzyme are adjacent to each other and remote from the active site, which is located between two domains. The polypeptide chain crosses over from one domain to the other twice. For ...

The optical dipole force from a singe focussed laser beam was used to study the role of laser-induced molecular alignment on the centre-of-mass motion of carbon disulphide molecules in a molecular beam. The translational, rotational and vibrational temperatures of the CS2 molecules were measured to be 3.4±0.2 K, 35±10 K and 250±14 K respectively. The velocity of the beam was measured to be 542±...

Circularly polarized slot cut rectangular microstrip antenna on thinner substrate is proposed. The dimensions of the slots are modified such that the resonance frequencies of the two orthogonal modes are close to each other to realize circular polarization. To improve upon the gain, three layer suspended configuration is proposed which yields VSWR and axial ratio BW of 40 and 9 MHz, respectivel...

Planar optical lenses are fundamental elements of miniaturized photonic devices. However, conventional planar optical lenses are constrained by the diffraction limit in the optical far-field due to the band-limited wavevectors supported by free-space and loss of high-spatial-frequency evanescent components. As inspired by Einstein's radiation 'needle stick', electromagnetic energy can be delive...

The new method for producing of the polarized relativistic positrons is suggested. A beam of unpolarized positrons accelerated up to a few GeV can be polarized during a head-on collision with an intense circularly polarized lazer wave. After a multiple Compton backscattering process the initial positrons may lose a substantial part of its energy and, as consequence, may acquire the significant ...

In modern wireless communication systems, small circularly polarized microstrip antennas with good performance are desirable mainly at low microwave frequencies. The radio frequency identification (RFID) systems in the ultra-high frequency (UHF) band have gained much interest in many services [Finkenzeller2004]. The reader antenna is one of the important components in the RFID reader system and...