Patients with mast cell activation syndrome (MCAS) often report having “brain fog,” which has been noted in other chronic illnesses. We previously identified evidence of cognitive dysfunction a small number MCAS patients via testing, though depression and anxiety are potentially confounders. sought to compare the presence rhinitis (CR) spontaneous urticaria (CSU) that MCAS. hypothesize similar ...

BACKGROUND IL-6 trans-signaling is critically involved in the initiation and promotion of inflammatory and autoimmune diseases. Therefore, we investigated the clinical relevance of soluble members of IL-6 trans-signaling system in chronic spontaneous urticaria (CSU). METHODS IL-6, interleukin 6 soluble receptor (IL-6 sR) and soluble gp130 (sgp130) were measured by ELISA method in plasma from ...

The introduction of omalizumab to the management of chronic spontaneous urticaria (CSU) has markedly improved the therapeutic possibilities for both, patients and physicians dealing with this disabling disease. But there is still a hard core of patients who do not tolerate or benefit from existing therapies and who require effective treatment. Novel approaches include the use of currently avail...

Chronic urticaria (CU) is a debilitating skin disease affecting around 1% of the population. CU can be subdivided into chronic spontaneous (CSU) and inducible (CIndU). Different pathophysiological mechanisms have been proposed to play role in development CU, these are also being investigated as potential biomarkers diagnosis management disease. As now only assessment tools available for treatme...

PURPOSE CD93 is receiving renewed attention as a biomarker of inflammation. We aimed to evaluate the potential for serum sCD93 to serve as a novel biomarker for allergic inflammation. MATERIALS AND METHODS We enrolled 348 subjects with an allergic disease [allergic rhinitis (AR), chronic spontaneous urticaria (CSU), or bronchial asthma (BA)], including 14 steroid-naïve BA patients who were se...

BACKGROUND AND OBJECTIVES Functionally active autoantibodies to IgE and to the high-affinity IgE receptor (FcεRI) can be detected in serum in about 40% of patients with chronic spontaneous urticaria (CSU). Recent studies showed that serum from patients with CSU can induce activation of mast cells, irrespective of whether they carry high-affinity IgE receptors. To evaluate mast cell activation i...

Background Spontaneous urticaria is a common allergic skin condition affecting 0.5-1% of individuals and may burden on health care expenditure or may be associated with remarkable morbidity. Aim In this study, we measured the effect of vitamin D supplementation in patients with a diagnosis of CSU. Furthermore, quality of life and cytokine changes were evaluated. Methods The clinical trial w...

Chronic spontaneous urticaria (CSU) is an immune-related skin disease characterized by abnormal activation of mast cells (MCs). With the advanced research on gut flora in diseases, it suggested that dysbiosis may contribute to pathogenesis CSU, but mechanisms involved are unknown. Butyrate, a metabolite flora, variety cellular physiological processes as histone deacetylase inhibitor (HDACi) and...

Background: Insufficient data are available on the long-term “real-life” safety profile of omalizumab in children. This study evaluated a pediatric cohort with severe asthma or chronic spontaneous urticaria (CSU). Methods: A monocentric, prospective patients aged 6–18 years. Each patient completed standardized MedDRA questionnaire to identify adverse events (AEs). Results: In total, 23 patients...