نتایج جستجو برای: chronic myeloproliferative disorder

تعداد نتایج: 1043759  

Journal: :Revista Brasileira de Hematologia e Hemoterapia 2012

2017
Muhammad Zeeshan

Introduction: Chronic myeloid leukemia abbreviated as CML is a type of myeloproliferative disease characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. It is a clonal bone marrow stem cell disorder in which a proliferation of mature granulocytes and their precursor is found. Case presentation: We...

2006
Chooi-Fun Leong Soon-Keng Cheong

Myelofibrosis is a chronic myeloproliferative disorder characterised by splenomegaly, leukoerythroblastic anaemia, tear-drop poikilocytosis and marrow fibrosis. Splenectomy is indicated for patients requiring frequent transfusions or massive splenomegaly causing distressing symptoms and severe thrombocytopenia secondary to hypersplenism. A 56 year-old lady diagnosed to have primary myelofibrosi...

2012
Shiva Raj

Correspondence: Dr. Reetu Baral, MD Department of pathology, KIST Medical College, Lalitpur, Nepal Email: [email protected] Idiopathic Myelofibrosis is an infrequent chronic myeloproliferative disorder characterized by varying degrees of bone marrow fibrosis and extra medullary hematopoiesis, with the fibrosis being a reactive phenomenon to a neoplastic proliferation of a pluripotent hemato...

2016
Ufuk Aydin Filiz Ata Derih Ay Yusuf Ata Tamer Turk Senol Yavuz

Essential thrombocytosis has been classified as a chronic myeloproliferative disorder. Patients with essential thrombocytosis undergoing cardiac surgery are at increased risk for bleeding and thrombosis. However, the incidence and treatment for this condition are not well known. There are profound implications of essential thrombocytosis in patients undergoing cardiac surgery with the use of ca...

Journal: :Expert review of anticancer therapy 2011
Jerry L Spivak Hans Hasselbalch

Hydroxycarbamide is a nonalkylating antiproliferative and antiviral agent that has been used for over 40 years to treat a variety of neoplastic and non-neoplastic conditions. Hydroxycarbamide is readily absorbed and widely distributed throughout the body. It acts primarily to inhibit DNA synthesis, which underpins its use in solid tumors, viral infections and chronic myeloproliferative disorder...

Journal: :Haematologica 2015
Tariq I Mughal Nicholas C P Cross Eric Padron Ramon V Tiu Michael Savona Luca Malcovati Raoul Tibes Rami S Komrokji Jean-Jacques Kiladjian Guillermo Garcia-Manero Attilio Orazi Ruben Mesa Jaroslaw P Maciejewski Pierre Fenaux Raphael Itzykson Ghulam Mufti Eric Solary Alan F List

In the 2008 WHO classification, chronic myeloid malignancies that share both myelodysplastic and myeloproliferative features define the myelodysplastic/myeloproliferative group, which includes chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, atypical chronic myeloid leukemia, refractory anemia with ring sideroblasts and thrombocytosis, and myelodysplastic/myeloproliferative un...

2013
Jason Gotlib Julia E. Maxson Tracy I. George Jeffrey W. Tyner

In clinical practice, neutrophilia most commonly relates to leukemoid reactions due to chronic infections, inflammatory diseases, or various types of malignancies. Cytokine-driven neutrophilia accompanying plasma cell neoplasms is a well-described association. Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm, with only ;200 patients reported to date, mostly culled from ...

Journal: :Blood 1985
R Morgan F Hecht M L Cleary J Sklar M P Link

A girl with Down's syndrome was born with a myeloproliferative disorder. The child had spontaneous regression of the myeloproliferation, with acute leukemia developing at a later date. Morphologic, cytochemical, immunologic, and immunoglobulin gene configuration studies all supported the diagnosis of acute nonlymphocytic leukemia. High-resolution chromosome studies revealed that the leukemic ce...

2012
Rosane Isabel Bittencourt Jose Vassallo Maria de Lourdes Lopes Ferrari Chauffaille Sandra Guerra Xavier Katia Borgia Pagnano Ana Clara Kneese Nascimento Carmino Antonio De Souza Carlos Sergio Chiattone

Chronic myeloproliferative diseases without the Philadelphia chromosome marker (Ph-), although first described 60 years ago, only became the subject of interest after the turn of the millennium. In 2001, the World Health Organization (WHO) defined the classification of this group of diseases and in 2008 they were renamed myeloproliferative neoplasms based on morphological, cytogenetic and molec...

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