Obesity is a global epidemic and coupled with the unprecedented growth of world’s older adult population, growing number individuals are both old obese. Whilst ageing obesity associated an increased prevalence chronic health conditions substantial economic burden, evidence suggests that coincident effects exacerbate negative outcomes. A significant contributor to such detrimental may be reducti...

INTRODUCTION The dose-response relationship suggests a toxic effect of alcohol on heart and liver and the possibility of a correlation between alcohol-induced liver and heart disease. The present study was aimed to look into the relationship between chronic liver and heart muscle disease among the non-moderate drinkers in our context. METHODS An observational study on non-moderate chronic dri...

OBJECTIVES Previous studies showed that skeletal muscle microcirculation was reduced in chronic heart failure. The aim of this study was to investigate the effects of endurance training on capillary and arteriolar density of fast and slow twitch muscles in rats with chronic heart failure. MATERIALS AND METHODS Four weeks after surgeries (left anterior descending (LAD) artery occlusion), chron...

The studies presented in this thesis have been approved by the Local Ethical Committee (KF 01-138/04), and conforms to The Declaration of Helsinki. The intervention study qualified for registration in the International Standard Randomised Controlled Trial Number Register: ISRCTN87055459. All subjects were informed about the purpose and content of the project and gave written informed consent. T...

Muscle hyperalgesia and referred pain play an important role in chronic musculoskeletal pain. New knowledge on the involved basic mechanisms and better methods to assess muscle pain in the clinic are needed to revise and optimize treatment regimens. Increased muscle sensitivity is manifested as pain evoked by a normally non-nociceptive stimulus (allodynia), increased pain intensity evoked by no...

AIMS To assess the prevalence and clinical impact of reductions in the skeletal muscle mass of patients with chronic heart failure (HF). Chronic HF is accompanied by co-morbidities that influence the quality of life and outcomes. METHODS AND RESULTS We prospectively enrolled 200 patients with chronic HF. The appendicular skeletal muscle mass of the arms and the legs combined, was assessed by ...

In nine patients with chronic compartment syndrome, the intramuscular pressure and muscle blood flow during constant dynamic exercise was studied by the microcapillary infusion method and by the 133-xenon clearance technique. Although muscle blood flow was normal at the start of exercise, pain and impaired muscle function eventually developed; muscle blood flow decreased while muscle relaxation...