Proteolytic enzymes have been proposed to play a role in the pathogenesis of various inflammatory pulmonary diseases accompanied by parenchymal remodeling. To assess the role of inflammatory cells and proteolytic enzymes in the development of chronic allograft rejection after lung transplantation, bronchoalveolar lavage fluid (BALF) samples from clinically stable lung transplant (LT) recipients...

BOS Stace ABSTRACT Chronic rejection evidenced as bronchiolitis obliterans syndrome (BOS) is the most common cause of allograft dysfunction alter lung transplantation (LTX). Currently, BOS is diagnosed indirectly based by pulmonary function tests. We investigated the potential of hyperpolarized helium-3 (H’He) MRI in assessing BOS in 13 LTX patients by correlating the percent H’He ventilation o...

PurposeChronic lung allograft dysfunction (CLAD) is the primary cause of long-term mortality after transplantation. Aspiration bile acids has been associated with CLAD and lipidomic dysregulation. This study evaluates role large airway bronchial wash (LABW) lipidomics diagnosis CLAD.MethodsLABW (n=611) samples were obtained from 305 transplant recipients at different timepoints. Concentrations ...