The relationship between chromosomal abnormality and oncogene activation was investigated during leukemic progression in two patients with myelodysplastic syndrome (MDS). Both patients had partial or complete deletion of chromosome 5 in metaphase cells obtained throughout the progression to leukemia. Analysis with specific oligonucleotide probes revealed that bone marrow cells containing an act...

Cytological, seed and epidermal studies were carried out of 9 taxa belonging to 4 genera 6 species the tribe Eupatorieae. Chromosome counts 2 species-Adenostemma caffrum (n=10) A. mauritianum are reported for first time from Nigerian flora report Ageratum conyzoides (n=18) differed earlier reports. The cytotypes in is flora. pollen fertility test all plants studied high this revealed that meios...

Of 1,036 children with newly diagnosed non-T, non-B acute lymphoblastic leukemia (ALL) and a demonstrated cytogenetic abnormality treated on the frontline Pediatric Oncology Group (POG) therapeutic trial 8602, there were 33 patients with trisomy 21 as the sole abnormality. Of these 33 ,14 had Down syndrome (DS). Although the nonDS (NDS) trisomy 21 cases tended to be older than the DS cases, the...

Several reports have described the occurrence of chromosome abnormalities in autism, a neuro-developmental disorder characterized by social deficits, communication impairment, and a restricted range of interests. These include the fragile X abnormality and 15q duplications. In this report, we describe two cases of chromosome 2q37 and review the literature on this topic. We propose that deletion...

Hemopoietic cells in chronic granulocytic leukemia (CGL) frequently contain a chromosome translocation involving chromosome 22 and another autosome, usually number 9. The translocated chromosome 22 is known as the Philadelphia (Ph) chromosome. The appearance of a second Ph chromosome is the most common cytogenetic abnormality in CGL signaling the blastic phase. For 6 yr we serially studied a ma...

Klinefelter syndrome is an abnormality of sexual development which is usually characterised by the chromosome complement 47,XXY. We present a case of a male patient with the phenotypic appearance of Klinefelter syndrome and primary infertility, who was found, on karyotype analysis, to have a hitherto undescribed inversion of the long arm of the X chromosome (46,Y,inv(X)(q12q25)). The underlying...

The Philadelphia chromosome (Ph') is of particular interest because of its close association with chronic granulocytic leukaemia. Ph' is a distinct chromosome abnormality which is found in the marrow or blood cells of nearly all patients with this leukaemia, and appears to be generally specific to this or closely related disorders. Because of these features, Ph', unlike the chromosome abnormali...