Structural abnormalities of the X chromosome are rarely found in neoplastic disorders. We describe three patients with a history of idiopathic acquired sideroblastic anemia (IASA); each one had an abnormal clone of cells in the bone marrow, characterized by a structurally abnormal X chromosome. In two of these patients, the predominant karyotype was 47,X,2idic(X)(q13); in the other patient, it ...

The frequency of chromosome abnormalities in spontaneous abortions, stillbirths, livebirths and among all clinically recognized pregnancies is given. Data on the parental origin of sex chromosome abnormalities and certain autosomal trisomies determined using molecular probes are presented and the proportion of sperm and eggs that are nullisomic or disomic for a sex chromosome to an autosome 16,...