objective: microdeletions of the y chromosome long arm are the most common molecular genetic causes of severe infertility in men. they affect three regions including azoospermia factors (azfa, azfb and azfc), which contain various genes involved in spermatogenesis. the aim of the present study was to reveal the patterns of y chromosome microdeletions in iranian infertile men referred to royan i...

eight accessions of thyme medicinal plant, belonging to iranian endemic thymus daënensis, t. eriocalyx, t. migricus and an unknown thymus spp species, were tested for karyotypic analysis, using squash technique and 2% (w/v) aceto-orcein staining method. chromosomal parameters examined were: short arm (s), long arm (l), total length of chromosome (tl), arm ratio (ar), r-value, total chromosome v...

Down syndrome is one of the most common causes of mental retardation observed in approximately 1/700 live birth. The use of two or more STR markers related to chromosome 21 facilitates the diagnosis of Down syndrome within about six hours from the collection of the samples. This is the first study has been performed in Iranian population to assess the diagnostic value of using small tandem repe...

Objective Approximately 15 percent of couples are infertile. The male factor is responsible for approximately 50% of the cases. One of the main genetic factors playing a role in male infertility is Y chromosomal microdeletion within the proximal long arm of the Y chromosome (Yq11), named azoospermia factor (AZF) region. Recent studies have also demonstrated that there is a potential connection ...

Background: The present study has been carried out to investigate the effects of preovulatory stage gamma-irradiation of female mice in the absence or presence of vitamin E on numerical chromosome abnormalities in 8-cell embryos after mating with non-irradiated males. Materials and Methods: The 8-11 weeks adult female NMRI mice were whole body irradiated at preovulatory stage (post PMSG inject...

Karyotype study was performed across 7 populations of 4 Rubus species growing in Iran. The results showed that the chromosome numbers of R. sanctus (2n=2x=14) diploid, R. caesius, and R. discolor were (2n=4x=28) tetraploids, R. persicus (2n=8x=56) octoploid. The chromosome numbers of R. discolor, and R. persicus were reported here for the first time. Karyotypic formula also varied between the s...

Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome. Here we have investigated XCI ratio in females with opioid addiction to see whether XCI skewness in women could be a risk factor for opioid addiction. Methods: 30 adult females meeting DS...

Background Monosomy is defined as the presence of only one chromosome instead of two in humans. Partial monosomy occurs when only a portion of the chromosome is present in a single copy, while the rest has two copies. It can occur in unbalanced translocations or deletions. Case report In this report, a 6 years old girl was presented who was referred to the Pediatric Dep, Shahid Sadoughi Ho...

Background: Many advances have been made in reproductive medicine yet the spontaneous loss of a pregnancy remains the most common complication of pregnancy. The aetiology of spontaneous recurrent pregnancy loss (RPL) is multifactorial. Y chromosome microdeletions are found in approximately 7% of men with low sperm counts and, compared to the general population, a higher frequency of spontaneous...