We immunohistochemically evaluated UTF1 in 104 primary and 68 metastatic testicular germ cell tumors and 339 non-germ cell tumors. The percentage of tumor cells stained was semiquantitatively scored (0, no tumor cell staining; 1+, ≤30% of cells; 2+, 31%-60% of cells; 3+, 61%-90% of cells; 4+, >90% of cells). Staining intensity (nuclear) was scored as weak, moderate, or strong. UTF1 staining was...

Introduction: Skeletal staining is an important part of anatomical studies which can evaluate macroscopic disorders in bones and cartilages development. The aim of the present article is to illustrate two distinct protocols by all details in order to stain skeletal system of the lab animals in all ages of their lives so it becomes easy for future studies in this field. Methods: In this pa...

Abstract BACKGROUND The new WHO 2021 classification included CDKN2A/B loss and TERT mutation as criteria for Grade 3 meningiomas, but excluded H3K27me3 loss. Malignant behavior may be influenced by DNA methyltransferases (DNMT3A). SUFU mutations carry a predisposition multiple meningiomas. METHODS In this retrospective study, 228 patients with 2, or recurrent 1 meningiomas resections from 1990 ...

Objective: Methotrexate (MTX), which is used as an immunosuppressive and anticancer drug, causes serious toxic side effects in many organs, including the kidney. Activation of apoptotic pathways through oxidative stress involved mechanism MTX mediated nephrotoxicity. In our study, we investigated protective ramelteon (RML), analogue melatonin, whose antioxidant antiapoptotic properties are well...

statement of problem: accumulation of plaque and staining due to a rough surface,  and  penetration  of  colourant  agents  from  food  and  beverages  in to the resin composite results in an incomplete polymerization. there is a little information on the effect of finishing and polishing techniques on the discoloration of nanohybrid and microhybrid composites when exposed to staining solutions...

  Abstract   Background: Squamous cell carcinoma (SCC) constitutes the main oral malignancy .   Parallel to better understanding of molecular and genetic patterns of tumor behavior, more precise correlation of tumor markers such as Epidermal Growth Factor (EGF) and Laminin-5 are sought to estimate macroscopic and microscopic tumor status .   Methods: We conducted a cross-sectional study collect...

abstract purpose: skeletal staining is a way to study the effect of many chemical or herbal substances on development of bones and cartilages in order to record the level of probable deformity.this article aimed to present a modified protocol to make all skeletal studies on laboratory animals possible. materials and methods: the important notes about skeletal staining were fixing by ethanol and...