in this study, a commercially available kit in which propionylthiocholine is used as a substrate and a dibucaine solution to determine the variants of the enzyme were utilized. plasma cholinesterase activity of 151 patients who underwent different operations was measured during a period of six months. the mean±sd of the enzyme activity in 150 patients was 4.39±1.17 ku/l .. seventeen patients (1...

There is growing evidence for the assumption that the profound biological effects produced by some compounds in low concentrations may be attributed to an interaction with enzymes. This is true for certain cell constituents as well as for toxic compounds not existing normally in the body. Several vitamins have been found to be prosthetic groups of enzymes and for a number of drugs it could be d...

There is growing evidence for the assumption that the profound biological effects produced by some compounds in low concentrations may be attributed to an interaction with enzymes. This is true for certain cell constituents as well as for toxic compounds not existing normally in the body. Several vitamins have been found to be prosthetic groups of enzymes and for a number of drugs it could be d...

The kinetic characteristic (Km) of cholinesterase from the crab Chasmagnathus granulata, the shrimp Farfantepenaeus paulensis and the fish Odontesthes bonaeriensis were compared and correlated with the anticholinesterasic effect of eserine (physostigmine). For the crustaceans, the estimated Km values were about 5-8 times higher than that estimated for the fish (0.04 mM). In the crab and the shr...

New N-allyl/propargyl 4-substituted 1,2,3,4-tetrahydroquinolines derivatives were efficiently synthesized using acid-catalyzed three components cationic imino Diels-Alder reaction (70-95%). All compounds were tested in vitro as dual acetylcholinesterase and butyryl-cholinesterase inhibitors and their potential binding modes, and affinity, were predicted by molecular docking and binding free ene...

The importance of Hypericum L. species, being used in traditional medicine, the scientific world is increasing day by day. species are plants that have been treatment many diseases for a long time and healing properties. In current study, essential oil compositions scabrum H. ternatum Poulter collected from different localities Turkey were determined GC-MS/FID. addition, their antioxidant, cyto...

In this work, previously synthesized tetra-chalcone-substituted metallophthalocyanines (MPcs) containing Ni(II), Zn(II), Co(II), and Cu(II) in the inner core were investigated anticholinergic activities against Alzheimer's disease (AD). The MPcs evaluated for their inhibition of acetylcholinesterase (AChE) butyrylcholinesterase (BChE) using original Ellman's colorimetric procedure. Against thes...

Enzymes hydrolysing acetylcholine have attracted much attention because acetylcholine is concemed with the functioning of the nervous system. The extensive literature on cholinesterases has been reviewed at intervals (Zeller, 1948; Koelle & Gilman, 1949; Augustinsson, 1950; Nachmansohn & Wilson, 1951; Whittaker, 1951; Davies, 1954; Bergmann, 1958; Davies & Green, 1958). Although there is ample ...