For warm-blooded species, the hazardous dose of a chemical (HD50) is an upcoming and important characteristic in the assessment of toxic chemicals. Generally, experimental information is available for a limited number of warm-blooded species only, which causes statistical uncertainty. Furthermore, when small datasets contain an unrepresentative sample of species, they can cause systematic uncer...

BACKGROUND The differential effects of so-called 'first- and second generation' antipsychotic medications, when given in the first episode, on the long-term outcome of schizophrenia remain to be elucidated. AIMS We compared the 9-year outcomes of individuals initially randomised to clozapine or chlorpromazine. METHOD One-hundred and sixty individuals with treatment-naive, first episode schi...

The introduction of chlorpromazine in Belgium and the Netherlands demonstrates an intriguing tango between old and new treatments. Chlorpromazine, marketed by the French company Rhône Poulenc entered psychiatry as an adjunct to existing therapies. Instead of promoting chlorpromazine as a revolutionary therapy, we see early efforts to market Largactil as a supplement to the armoury of psychiatri...

Rabbits were fed an atherogenic diet concurrently with chlorpromazine for 2 weeks (10 mg/kg/day in the diet) or 12 weeks (20 mg/kg/day given orally in a single capsule). After 2 weeks, arterial acyl CoA: cholesterol acyltransferase (ACAT) activity tended to be reduced by chlorpromazine treatment with no affect on net arterial cholesterol. After 12 weeks of treatment, arterial ACAT activity was ...

This study was performed to evaluate the ability of chlorpromazine compound cure plasmids and remove antibiotic resistance character multidrug Gram-negative pathogenic bacteria. The curing experiment done by incubating bacterial strains in nutrient broth with sub MIC concentration chlorpromazine, disc diffusion method used before after pattern Synergetic test antibiotics that studied bacteria s...

Major use Chlorpromazine hydrochloride (CPH) belongs to antipsychotic drugs, also called neuroleptics; and it is mainly used for the treatment of neurological disorders. CPH has sedative, hypotensive and antiemetic properties. CPH, which is an aliphatic phenothiazine, was first synthesized in 1952. It was extensively studied and used as a model for a big class of neuroleptic agents. Haloperidol...

Purpose: To investigate the effect of Flueggea leucopyrus Wild aqueous extract (FLAE) on the urinary output of rats. Method: Three different doses of FLAE (500, 1000 and 1500 mgkg), furosemide (13 mg kg as diuretic reference) and distilled water (as control) were orally administered to healthy adult hydrated rats. Cumulative urine output was monitored hourly over 6 h. Selected urinary parameter...

Derivatives of IS!-substituted phenothiazine are concentrated in the tissues of the uveal tract of pigmented animals. The concentration levels for phenothiazine in the uveal tissue may reach 50 times the mean distribution value even 48 hours after a single dose of 5 mg. per kilogram. All other tissues have lower concentration levels than the mean distribution value. Only samples involved in exc...