DURING the past decade the drug treatment of psychiatric illness has advanced with remarkable rapidity. The principal drugs concerned are those with predominant actions on higher mental and neurological functions and collectively referred to as psychotropic drugs. The main drugs used in practice can be classified into (i) Anti-psychotic drugs (Neuroleptics). (2) Anti-depression drugs. (3) Anti-...

Chlorpromazine (3 x 10(-4)M) prevents the stimulation of adenyl cyclase activity in thyroid membranes produced by thyrotropin and prostaglandin, ACTH stimulation of adenyl cyclase in adrenal tissue, and glucagon- and epinephrine-stimulation of adenyl cyclase activity in liver. Baseline activity is unaffected. Parathyroid hormone stimulation of kidney preparations was not inhibited under these c...

The roots of 7-d seedlings of two winter wheat cultivars differing in frost resistance were used to study changes in lectin activity using the inhibitor of microtubule polymerization oryzalin (15 μM) in unhardened (23oC) and hardened (2–3oC, 3–7 d) plants. Plants were grown with the antagonist of calmodulin, chlorpromazine (250 μM) or without chlorpromazine in medium. It was shown that the dyna...

Chlorpromazine is a phenothiazine antipsychotic which is often used in hospice and palliative care to treat hiccups, delirium, and nausea. With the discontinuation of the commercial oral solution concentrate, there is a need to prepare this product by extemporaneous compounding. This study was initiated to identify an easy-to-prepare formulation for the compounding pharmacist. A stability study...

Numerous reports including Courvoisier et al. (1) have been made of the pharmacolo gical studies on chlorpromazine. The action of chlorpromazine on the central nervous system has been studied in reference to electroencephalography and evoked potentials from the brain of animal. Although the action mechanism of the drug has been well explained, much seems still left unclarified. The most conspic...

The purpose of this paper is to focus on the short-term effects of chlorpromazine on erythrocytes because it is reported that the drug, unstable in plasma but more stable in erythrocytes, interacts with erythrocyte membranes, membrane lipids, and hemoglobin. There is a rich literature about the side and therapeutic effects or complications due to chlorpromazine, but most of these studies explor...

Previous investigations have demonstrated the ability of atropine and chlorpromazine pretreatment to increase intravenous cocaine self-administration in rhesus monkeys. These results were interpreted as resulting from either an antagonism of cocaine's reinforcing effect or an effect of cocaine which may interfere with its self-administration. The generality of the postulated drug antagonism was...

Liver ischemia in intact rats is associated with a series of alterations in mitochondrial structure and function that include: a complete loss of respiratory control; a loss of adenine nucleotide translocase activity; decreases in, at least, the heme portions of cytochromes aa and c + cl; a decrease in dinitrophenolactivated ATPase; a loss of the ability of dinitrophenol to stimulate 02 uptake;...

1. Phosphatidate phosphohydrolase from the particle-free supernatant of rat liver was assayed by using emulsions of phosphatidate as substrate. 2. The inhibition of the phosphohydrolase by chlorpromazine was of a competitive type with respect to phosphatidate. The potency of various amphiphilic cationic drugs as inhibitors of this reaction was related to their partition coefficients into a phos...