CONTEXT Scyphiphora hydrophyllacea is a shrub mangrove plant of the family Rubiaceae and not yet been studied for anti-hepatocarcinogenic effects. OBJECTIVES We investigated possible in vitro anti-hepatocarcinogenic and antioxidant properties of S. hydrophyllacea. MATERIALS AND METHODS Dried leaves of S. hydrophyllacea were sequentially extracted into hexane, chloroform, ethyl acetate, and ...

The effect of chloroform on Ca(2+) mobilization in Madin-Darby canine kidney cells was examined by using Fura-2 as a Ca(2+) probe. Chloroform (24-248 mM) concentration dependently increased intracellular Ca(2+) concentration ([Ca(2+)](i)). Ca(2+) removal inhibited the Ca(2+) signals evoked by 93 to 248 mM chloroform by reducing both the initial rise and the sustained phase. In Ca(2+)-free mediu...

A recent study of the ability of chloroform in drinking water to produce cancer reported that male Osborne-Mendel rats developed renal tumors, but that female B6C3F1 mice failed to develop hepatocellular carcinomas. The results obtained in the male Osborne-Mendel rats were comparable to those observed in an earlier study sponsored by the National Cancer Institute (NCI). On the other hand, the l...

From its introduction in 1847, chloroform proved to be a potent anaesthetic agent and over the next 50 yr its use became widespread. However, in 1912 the Committee on Anaesthesia of the American Medical Association stated that they were concerned with the occurrence of delayed chloroform poisoning in a number of cases. This conclusion was based on case reports and experimental animal data. Howe...

objective: application of chemical solvents especially in problematic canals is usually a part of the retreatment process.this study was performed to compare the solubility of gutta- percha and resilon in chloroform and to find the effect of sample thickness as well as the time of shaking on their solubility. materials and methods: specific weight of resilon and gutta-percha was placed in a sam...

In spite of many investigations concerning the distribution and fate of anesthetic and lethal doses of chloroform in animal fluids, tissues, and organs,l there have been relatively few accurate quantitative determinations of the amounts of chloroform in various parts of the animal body following chloroform poisoning. The most reliable data are evidently those reported by Buckmaster and Gardner ...

The antimicrobial activity and preliminary phyto-chemical studies on whole plant of Stachytarpheta jamaicensis were evaluated. The shade dried and coarsely powdered plant was successively extracted with n-hexane, chloroform and alcohol in Soxhlet apparatus. The antimicrobial activity of chloroform and alcohol extracts were evaluated by disc diffusion method and the MIC was determined. Prelimina...

OBJECTIVES Recently, bioceramic sealers like EndoSequence BC Sealer (BC Sealer) have been introduced and are being used in endodontic practice. However, this sealer has limited research related to its retreatability. Hence, the aim of this study was to evaluate the retreatability of two sealers, BC Sealer as compared with AH Plus using micro-computed tomographic (micro-CT) analysis. MATERIALS...

The nongenotoxic-cytotoxic carcinogen chloroform induces liver necrosis, regenerative cell proliferation, and, eventually, liver tumors in female B6C3F1 mice when administered by gavage at doses of 238 or 477 mg/kg/d. Administration of 1800 ppm of chloroform in the drinking water results in similar daily doses but does not produce liver toxicity or cancer. The differential-display technique was...