We analyzed mutations of 7 vitamin K-dependent protein and cytochrome P450 2C9 genes in 45 patients and investigated whether any contribute to the large interpatient variability in the warfarin dose-effect relationship. Total clearance and daily dose, INR and INR/Cp, were used as pharmacokinetic and pharmacodynamic indexes, respectively. Patients were grouped by genotype based on a single polym...

Coronary artery aneurysms (CAAs) are rare dilations of arterial segments. These aneurysms are mostly caused by atherosclerosis. Due to the rarity of this condition, there are no official guidelines for its management; therefore, management is mainly based on case reports. We present a patient with a giant CAA in the left anterior descending artery who was treated medically. At 12-month follow-u...

Long-term insulin treatment selectively stimulates secretion of the truncated form of apolipoprotein B (apoB), apoB-48, from primary rat hepatocytes in culture. Chronic treatment with insulin at 400 ng/ml causes a 3-fold increase in total apoB secretion, with apoB-48 making up about 75% of that increase. apo-B-48 is the protein product generated by translation of full-length apoB mRNA which has...

237-40. 4. Hunt DM, Higgs DR, Winichagoon P, Clegg JB, Weatherall DJ. Haemoglobin Cs Sp has an unstable α chain messenger RNA. Br J Haematol 1982; 51:40513. 5. Harteveld CL, Traeger-Synodinos J, Ragusa A, et al. Multicentric origin of Hb Constant Spring [α2 codon 142 TAA-CAA]. Br J Haematol 1998; 102:50. 6. Pootrakul P, Winichagoon P, Fucharoen S, Pravatmuang P, Piankijagum A, Wasi P. Homozygou...

Source and Description of Sequence Polymorphism: Nucleotide sequencing of type HI procollagen (COL3A1) cDNAs from several individuals revealed a nucleotide polymorphism that converted the codon for amino acid 581 of the triple helix from -GGC(C-allele) (1) to -GGT(T-allele) in some alleles. The PCR was carried out with primers below; cDNA products were 226 bp and genomic products were 326 bp in...

The monochloroacetic, dichloroacetic and trichloroacetic acid (MCAA, DCAA and TCAA) removed by metallic iron under controlled dissolved oxygen conditions (0, 0.75, 1.52, 2.59, 3.47 or 7.09 mg/L DO) was investigated in well-mixed batch systems. The removal of CAAs increased first and then decreased with increasing DO concentration. Compared with anoxic condition, the reduction of MCAA and DCAA w...

Zeolites are the best known microporous molecular sieves and adsorbe molecules below a particular size in their pore structures. Therefore they are considered as heterogenous catalysts and sorbents [1]. The catalytic properties of zeolites can be understood by investigating the adsorption characteristics of reactions on their surfaces [2, 3]. During the past years the adsorption of some compoun...

The European funded PePCAA project developed a series of scenario-based computer delivered formative assessments of pedagogical psychology for teachers and trainee teachers, using a range of software features, including the addition of confidence measurement. Scenarios were based on realistic classroom situations and focused on problem solving or on utilising best practice. The PePCAA Learning ...

This is part of a series of two papers on gene regulation in Bacillus subtilis rRNA-tRNA operons that contain large clusters of tRNA genes. The preceding paper (Vold, B.S., Okamoto, K., Murphy, B.J., and Green, C.J. (1988) J. Biol. Chem. 263, 14480-14484) investigates the rrnB operon containing 21 tRNA genes, and this paper investigates a B. subtilis rRNA-tRNA operon containing 16 tRNA genes an...

During this semester, ten reactions were carried out. The first was the synthesis of D-glyceraldehyde acetonide from D-mannitol. The next six reactions were involved with the synthesis of the corresponding γ-lactone of glyceraldehyde acetonide. The final three reactions were attempted syntheses of ethyl ethynyl ether, the key starting material in the synthesis of TMS ketene. Introduction In the...