objective(s): the purpose of this study is about the preparation and evaluation of nanoparticles composed of thiolated methylated pyridinyl chitosan (tmpc) which are made p.e.c method, for bucal drug delivery of insulin.materials and methods: first of all have to synthesize methylated pyridinyl chitosan and then for (tmpc) l-cysteine should be attached to methylated pyridinyl chitosan by the fo...

Introduction: Dual-modality contrast agents, such as radiolabeled nanoparticles, are promising candidates for a number of diagnostic applications, namely SPECT imaging with MR imaging. So the aim of study was evaluating potential of Chitosan-Coated Magnetic Nanoparticles(SPION) labeled with 99mTc as new Dual-modality probes for liver Imaging. Materials and Methods:</st...

The formation of electrostatic interactions between polyanionic siRNA and polycations gives an easy access to the colloidal particles capable delivering in vitro or vivo. Among used for delivery, chitosan occupies a special place due its unique physicochemical biological properties. In this chapter we describe fundamental practical aspects complexes siRNA. basis complexation oppositely charged ...

Abstract Background Nano-particles of metals can be routinely synthesized. The cereal seeds treatment with the particles improve early growth and crop production. Moreover, is robust economical. Methods Metal (Fe 0 , Cu Co ), zinc oxide (ZnO) chitosan-stabilized silver nano-particles were synthesized applied to seeds. germination rate, plant development inhibition effects on pathogenic fungi qu...

Iron (Fe) loaded solid lipid nanoparticles (SLN's) were formulated using stearic acid and iron absorption was evaluated in vitro using the cell line Caco-2 with intracellular ferritin formation as a marker of iron absorption. Iron loading was optimised at 1% Fe (w/w) lipid since an inverse relation was observed between initial iron concentration and SLN iron incorporation efficiency. Chitosan (...

BACKGROUND The highly reactive aldehyde acrolein is a very potent endogenous toxin with a long half-life. Acrolein is produced within cells after insult, and is a central player in slow and progressive "secondary injury" cascades. Indeed, acrolein-biomolecule complexes formed by cross-linking with proteins and DNA are associated with a number of pathologies, especially central nervous system (C...

Covalent grafting of biomolecules is a strategy to improve the biocompatibility and bioactivity of materials. However, it is critical to maintain the biological activity of the biomolecule upon its attachment to the surface. In the present study we compared the biological properties of chitosan, in which the surface was enriched with fibronectin (Fn), using two methodologies: chemical immobiliz...

Nanospheres are being developed for the oral delivery of peptide-based drugs such as insulin. Mucoadhesive, biodegradable, biocompatible, and acid-protective biomaterials are described using a combination of natural polyelectrolytes, with particles formulated through nanoemulsion dispersion followed by triggered in situ gel complexation. Biomaterials meeting these criteria include alginate, dex...

Objective- The healing effect of chitosan supported cerium oxide nanoparticles (nano-CeO2) on cutaneous experimental excisional wound infected with pseudomonas aeruginosa was studied in rat. Design- Experimental Study. Animals- Sixty male albino rats. Procedures- The chitosan supported nano-CeO2 hydrogel was prepared and characterized using Fourier-transform infrared spectro...