نتایج جستجو برای: chitosan nanocapsules and cytotoxicity

تعداد نتایج: 16836846  

2013
Midhun B Thomas Krishna Radhakrishnan Divya P Gnanadhas Dipshikha Chakravortty Ashok M Raichur

A novel polyelectrolyte nanocapsule system composed of biopolymers, chitosan and heparin has been fabricated by the layer-by-layer technique on silica nanoparticles followed by dissolution of the silica core. The nanocapsules were of the size range 200 ± 20 nm and loaded with the positively charged anticancer drug doxorubicin with an efficiency of 89%. The loading of the drug into the capsule h...

2010
Xin-Cai Xiao Zong-Guo Hong

We developed a novel method to prepare nanocapsules. A solute often crystallizes when its solubility alters from one solvent to another, and its firstborn crystals are used as templates to prepare nanocapsules for the first time, which is called firstborn microcrystallization method. By using this method, the maximum diameter of the nanocapsules including artesunate is about 76 nm, and wrapping...

Journal: :Nanotechnology 2013
Franciele de Paula Pansani Oliveira Isadora Pfeifer Dalla Picola Qin Shi Hellen Franciane Gonçalves Barbosa Vera Aparecida de Oliveira Tiera Júlio Cesar Fernandes Marcio José Tiera

Chitosan has been indicated as a safe and promising polycation vector for gene delivery. However its low transfection efficiency has been a challenging obstacle for its application. To address this limitation, we synthesized chitosan derivatives which had increasing amounts of diethylethylamine groups (DEAE) attached to the chitosan main chain. The plasmid DNA VR1412 (pDNA), encoding the ß-gala...

Journal: :International journal of biological macromolecules 2011
Joao C Fernandes Margarida Borges Henrique Nascimento Elsa Bronze-da-Rocha Oscar S Ramos Manuela E Pintado F Xavier Malcata Alice Santos-Silva

Two COS mixtures and a low molecular weight chitosan (LMWC) were tested for potential cytotoxicity and genotoxicity upon human lymphocytes. Genotoxicity was evaluated in vitro by cytokinesis-blocked micronucleus and alkaline comet assays, while cytotoxicity was assessed by flow cytometry analysis. Our results suggest that COS do not exhibit any genotoxicity upon human lymphocytes, independently...

Journal: :European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2014
Zahra Merchant Kevin M G Taylor Paul Stapleton Sana A Razak Nitesh Kunda Iman Alfagih Khalid Sheikh Imran Y Saleem Satyanarayana Somavarapu

The potential of amphiphilic chitosan formed by grafting octanoyl chains on the chitosan backbone for pulmonary delivery of levofloxacin has been studied. The success of polymer synthesis was confirmed using FT-IR and NMR, whilst antimicrobial activity was assessed against Pseudomonas aeruginosa. Highly dispersible dry powders for delivery as aerosols were prepared with different amounts of chi...

Journal: :Medicine in drug discovery 2022

• When PLA/PEG/Chitosan/FA/DNA nanoparticles interact with MCF-7 cells, their loading percentage and biocompatibility improve. Physicochemical properties of for properly targeted transfer to cells. An increase in Chitosan-FA on gene efficiency was seen positively by nanoparticles. The ability Chitosan-Folic acid PLA-PEG polymers delivery into cells evaluated. copolymer is one the most appealing...

2012
Jingjing Jiang Han Wang Huaihong Guo Teng Yang Wen-Shu Tang Da Li Song Ma Dianyu Geng Wei Liu Zhidong Zhang

The microwave absorption properties of Ni/(C, silicides) nanocapsules prepared by an arc discharge method have been studied. The composition and the microstructure of the Ni/(C, silicides) nanocapsules were determined by means of X-ray diffraction, X-ray photoelectric spectroscopy, and transmission electron microscope observations. Silicides, in the forms of SiOx and SiC, mainly exist in the sh...

Journal: :Langmuir : the ACS journal of surfaces and colloids 2010
Polina B Smith Kimberly A Dendramis Daniel T Chiu

This paper describes characterization of lyophilized lipid nanocapsules loaded with Alexa 488 by fluorescence correlation spectroscopy (FCS). Fluorimetry analysis of nanocapsules containing self-quenching concentrations of 5- and 6-carboxyfluorescein was performed to establish a point of reference for FCS. FCS results complemented the results obtained by fluorimetry for a bulk nanocapsule solut...

Kannaiyan Sathish Kumar, Vasudevan Jaikumar

The present study is aimed at the overall improvement in the efficacy, reduced toxicity and enhancement of therapeutic index of cisplatin. Nanocapsules of cisplatin containing ethylcellulose have been prepared using solvent evaporation technique under ambient conditions. The prepared nanocapsules were used for controlled drug release of anticancer agents with gold and iron oxide nanoparticles. ...

Journal: :Molecules 2014
Lúcia Raquel Ramos Berger Thayza Christina Montenegro Stamford Thatiana Montenegro Stamford-Arnaud Luciana de Oliveira Franco Aline Elesbão do Nascimento Horacinna M de M Cavalcante Rui Oliveira Macedo Galba Maria de Campos-Takaki

Microbiological processes were used for chitin and chitosan production with Cunninghamella elegans UCP/WFCC 0542 grown in different concentrations of two agro-industrial wastes, corn steep liquor (CSL) and cassava wastewater (CW) established using a 2² full factorial design. The polysaccharides were extracted by alkali-acid treatment and characterized by infrared spectroscopy, viscosity, therma...

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