In this work, natural-based and biodegradable nanofibers were produced by electrospinning for drug delivery wound dressing applications, using gelatin (Gel), chitosan (CS), cellulose nanocrystals (CNC) natural propolis extract. The polymeric formulations parameters optimized, resulting in the development of Gel/CS with mean diameters 97 nm. CNC successfully introduced into optimized solution vi...

This review article aimed to study chitosan as a material based in wound dressing preparation. The method this is the approximation method. articles were obtained from national and international journals such Scopus, PubMed, Google Scholar by using keywords "Chitosan", "Wound Healing", "Biomedical Application". inclusion criteria of are: books contains as, published last ten years, not article....

For an improved understanding of the relevant particle features for cutaneous use, we studied the effect of the surface charge of acrylic nanocapsules (around 150nm) and the effect of a chitosan gel vehicle on the particle penetration into normal and stripped human skin ex vivo as well as local tolerability (cytotoxicity and irritancy). Rhodamin-tagged nanocapsules penetrated and remained in th...

Long time uptake arsenic will cause cancers and blackfoot disease. There are still several million people suffering from drinking arsenic ontaminated water. This work studied the performance of coupled chitosan/UF for arsenic removal and the influence of dissolved organic matter n arsenic removal with UF operation. Humic acid representing dissolved organic matter was fractionated into five grou...

This study concerns the development and charaterization of Silica-based aldehyde Chitosan hybrid material as an adsorbent for biodiesel purification. This biocomposite was prepared by sol-gel route and oxidation with periodate, and then characterized. FTIR experiments showed that the hybrid formed presents absorption bands similar to those of Chitosan-Silica, with the exception of the vibration...

Topical administration of clotrimazole represents the common use therapy in the antimycotic genitourinary tract treatment. Due to the fast self-cleaning action of the vagina, commercially available vaginal dosage forms with clotrimazole cannot assure prolonged contact time with mucosa, therefore the main objective of this study was to develop a dosage form for vaginal administration of clotrima...

Degenerative disc disease has been implicated as a major component of spine pathology. However, although biological repair of the degenerate disk would be the ideal treatment, there is no universally accepted scaffold for tissue engineering of the intervertebral disk. To help remedy this, we investigated the gelation kinetics of various concentrations (2.5 to 10%) of two water-soluble chitosan ...

Objective: In an attempt to optimize the anti-Alzheimer effect, rivastigmine-loaded chitosan nanoparticles were developed in order target of brain through skin permeation. Methods: Rivastigmine-loaded chitosan-tripolyphosphate prepared by modified ionic gelation method using tween 80 surfactants different batches with variable chitosan/cross-linker ratios, desirability factors applied choose op...

Temperature-responsive polymers are attractive candidates for applications related to injectable delivery of biologically active therapeutics, such as stem cells. In this study, we evaluate the potential of thermosensitive hydroxybutyl chitosan (HBC) as a biomaterial for the culture of human mesenchymal stem cells (hMSC) and cells derived from the intervertebral disk, with the eventual goal of ...

The Mark–Houwink–Sakurada (MHS) equation allows for estimation of rheological properties, if the molecular weight is known along with good understanding of the polymer conformation. The intrinsic viscosity of a polymer solution is related to the polymer molecular weight according to the MHS equation, where the value of the constants is related to the specific solvent and its concentration. Howe...