Programs of drug discovery generally exploit one enantiomer of a chiral compound for lead development following the principle that enantiomer recognition is central to biological specificity. However, chiral promiscuity has been identified for a number of enzyme families, which have shown that mirror-image packing can enable opposite enantiomers to be accommodated in an enzyme's active site. Re...

The dicatechol ester ligand 2-H4 forms the compressed helicate Li4[(2)3 Ti2] which upon removal of internally bound lithium cations expands. In form, chiral diol units control stereochemistry complex is lost expansion system.

The high performance liquid chromatography (HPLC) enantioseparation of four β-blocking agents metoprolol, bisoprolol, propranolol and atenolol was performed on amylose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase using n-hexane-ethanol-diethylamine (DEA) as the mobile phase and related chiral recognition mechanisms were discussed. Enantiomeric separation of the fourβ-blockers was ...

   In chiral and non-chiral electrophoretic resolution of basic drugs, adsorption of analytes to negatively charged capillary wall could lead to poor repeatability of migration time and peak area. In addition, chiral resolutions of basic drugs are commonly performed in low pH buffers. Therefore, longer analysis time due to suppression of electroosmotic flow (EOF) is another dilemma. In this wor...

In this research, the influence of structure on the tensile properties of single- walled carbon nanotubes (CNTs) is evaluated using molecular mechanics technique and finite element method. The effects of diameter, length and chiral angle on elastic modulus and Poisson’s ratio of armchair, zigzag and chiral structures are investigated. To simulate the CNTs, a 3D FEM code is developed using the A...

A methodology is given to test the QCD Nf=2 chiral transition, presently conjectured to be second order. Scaling forms for the correlation length, susceptibilities and equation of state are given which account for finite lattice spacing. Confirmation by lattice simulation would provide a large set of consistency checks for establishing that the transition is second order. Further corrections fr...

Essential oil of Juniperus oxycedrus growing in Algeria was obtained by steam distillation extraction method. The oil was analysed by capillary columns (non-polar DB5 and HP-chiral-20B) using gas chromatography with flame ionization and mass spectrometric detections. The compounds were identified according to their retention indices and mass spectra (EI, 70 eV). The oil contained α-pinene (36.7...

abstractthe liquid crystal director distribution is determined for a confined chiral nematic slab. the molecular director distribution of the field-controlled chiral nematic slab is directly calculated. the director profiles for the tilt and the twist angles, under different applied fields, are calculated in the slab with weak boundary conditions. then, the dependence of the threshold field on ...

Enantiomers as a optically active forms of drugs now have a big impact on most areas of pharmacotherapy. They arouse a large interest in the field of psychiatry and especially in the treatment of depression. This is due to the fact that enantiomers (chiral forms) of many drugs may have a different pharmacokinetic, pharmacological or pharmacogenetic profiles. Therefore, in many cases the use of ...

Over recent years there has been a tendency to target the development of chiral materials for use in healthcare treatments. In such applications and therapies the optical purity is an important factor to consider. Two common materials, that have relevance in bio-medical applications, and which are available in their chiral and racemic forms are menthol and ibuprofen. In this article we quantita...