BACKGROUND Loperamide is widely used in adults for acute diarrhea. However, its use in children has been discouraged by the World Health Organization and the American Academy of Pediatrics owing to concerns over safety and efficacy in young children. METHODS AND FINDINGS To assess the efficacy and adverse effects of loperamide compared with placebo for acute diarrhea in children, we reviewed ...

The objective of this study was to evaluate an algorithm for the management of children with persistent/chronic diarrhea at a community level hospital. The study was carried out in the pediatric OPD of a 150 bed trust hospital catering to children from poor, rural and urban slums. Fifty clinically stable children (6 months-5 years old, mean = 19.7 months) with persistent or chronic diarrhea ref...

In 1976, Jon Rohde, highlighting the importance of diarrhea as a prime killer of children in the developing world, beckoned the scientific community to "take science where the diarrhea is!" [1]. While researchers were discovering many new etiologic agents that cause diarrhea, progress in preventing diarrheal deaths-then estimated at about 5 million per yearwas slow. Twenty years later, despite ...

From May to August 1999, we evaluated 401 patients from a pediatric hospital of Havana City. One group was composed of 113 patients with diarrhea admitted to the Gastroenterology ward and a second consisted of 288 patients without diarrhea, admitted for other reasons, and hospitalized within the same time period. Three stool samples were collected from each child and were examined using three p...

Objective: To compare the efficacy of zinc-probiotic combination therapy and probiotic alone in treatment acute pediatric watery diarrhea. Study Design: Randomized Clinical Controlled trial. Setting: The study was completed at Department Pediatrics, Unit I, Bolan Medical Complex Hospital, Quetta, Pakistan from July 2021 to January 2022. Methodology: A total number 144 children either gender age...

We describe the characterization of 126 atypical enteropathogenic Escherichia coli (aEPEC) isolates from 1,749 Brazilian children. Classic aEPEC strains were more frequently found in children with diarrhea than in controls (P < 0.001), showing their importance as acute diarrhea agents in our country. Only aEPEC strains carrying either the ehxA or paa gene were significantly associated with diar...

Acute respiratory infections, diarrhea and fever are very common in children below the age of five years. All children suffer from these illnesses several times each year. However, during natural disasters like floods children are even more vulnerable to these diseases and death. Pneumonia, diarrhea, measles and malaria, and associated malnutrition, are responsible for over 60% deaths in childr...

Background: Well-controlled clinical studies in the developed world have shown that probiotics can shorten the duration of acute non-bacterial diarrhea. We aimed to evaluate the efficacy of a probiotic consisting of a mixture of Lactobacillus acidophilus and Bifidobacterium bifidum in the treatment of young children with acute diarrhea in Mashad, Iran Methods: Sixty-two hospital inpatients aged...

BACKGROUND AND OBJECTIVES A vicious cycle of infection, malabsorption, and malnutrition has been implicated in the perpetuation of diarrheal disease. This study examined whether persistent diarrhea is associated with changes in selenium status and stool alpha-1 antitrypsin (AAT) concentration. METHODS AND STUDY DESIGN This cross-sectional study included 30 children aged 1-12 years with persis...