Pectin is a dietary fibre composed of galacturonic acid, primarily found in the citrus fruits' cell walls. Citrus pectin (CP) has demonstrated antioxidative, anticancer, and anti-inflammatory properties humans animals. In broilers, CP supplementation improves energy utilization nutrient digestibility, but limited information on its effects chicken immunity available so far. This study aimed to ...

Neutrophil function. The neutrophil response to infection in vivo is initiated by adherence of the neutrophils to vascular endothelia, progresses to the directed migration of the neutrophils into the extravascular tissue space, and culminates in neutrophil-mediated phagocytosis and intracellular killing of the invading microorganisms. An assay for the in vitro study of phagocytic capacity is pr...

In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As the pH of microenvironment alters, the functions of immune cells are about to change. It makes the extracellular acidification a key modulator of innate immunity. Here we detected the impact of extracellular acidification on neutrophil apoptosis and functions, inclu...

statement of problem: papillon lefevre syndrome (pls) is a rate autosomal recessive disorder, which is characterized by palmar- plantar hyperkeratosis and rapid periodontal destruction of primary and permanent dentitions. purpose: the aim of the present study was to evaluate the peripheral blood neutrophil function including random locomotion, chemotaxis and oxidative mechanism of killing in a ...

tients are at higher risk for various infections than nondiabetic patients. Reviews of this subject have concluded that data supporting a higher risk for many infections in diabetes are inadequate . Immunologic research has, however, demonstrated several defects in host immune defense mechanisms in diabetic subjects. Phagocytic capabilities of polymorphonuclear leukocytes (PMN) are adversely af...

Thymus species are popular spices and contain volatile oils as main chemical constituents. Recently, plant-derived essential oils are gaining significant attention due to their significant biological activities. Seven different thymus-derived essential oils were compared in our study. First, we focused on their chemical composition, which was followed up by testing their effects on phagocytosis...

Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain's innate immune response against infection, injury, and diseases. Microglia respond to extracellular signals and engulf unwanted neuronal debris by phagocytosis, thereby maintaining normal cellular homeostasis in the CNS. Pathological stimuli such as neuronal inju...

Transcriptional regulatory networks (TRN) control the underlying mechanisms behind cellular functions and they are defined by a set of core transcription factors regulating cascades of peripheral genes. Here we report SPI1, CEBPA, MNDA and IRF8 as core transcription factors of monocyte TRN and demonstrate functional inductions of phagocytosis, inflammatory response and chemotaxis activities in ...

Background: H pylori is a human gastric pathogen. Chemotaxis is an essential factor in colonization of H pylori, but very little is known about its chemotactic responses at different pH conditions, especially in acidic environment of stomach as its natural habitant. Methods: We first determined survival of H pylori under various pH conditions in the presence and absence of urea.  Chemotaxis was...