نتایج جستجو برای: chemoresistance

تعداد نتایج: 5112  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
S Song M G Wientjes Y Gan J L Au

Based on the observation that removal of tumors from metastatic organs reversed their chemoresistance, we hypothesized that chemoresistance is induced by extracellular factors in tumor-bearing organs. By comparing chemosensitivity and proteins in different tumors (primary vs. metastases) and different culture systems (tumor fragment histocultures vs. monolayer cultures derived from the same tum...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Bin Li Wen Wen Xu Xin Yuan Guan Yan Ru Qin Simon Law Nikki Pui Yue Lee Kin Tak Chan Pui Ying Tam Yuk Yin Li Kwok Wah Chan Hiu Fung Yuen Sai Wah Tsao Qing Yu He Annie L M Cheung

PURPOSE Chemoresistance is a major obstacle in cancer therapy. We found that fluorouracil (5-FU)-resistant esophageal squamous cell carcinoma cell lines, established through exposure to increasing concentrations of 5-FU, showed upregulation of Id1, IGF2, and E2F1. We hypothesized that these genes may play an important role in cancer chemoresistance. EXPERIMENTAL DESIGN In vitro and in vivo fu...

2017
Nathan P. Gossai Peter M. Gordon

Acute lymphoblastic leukemia (ALL) is the most common cancer in children. While survival rates for ALL have improved, central nervous system (CNS) relapse remains a significant cause of treatment failure and treatment-related morbidity. Accordingly, there is a need to identify more efficacious and less toxic CNS-directed leukemia therapies. Extensive research has demonstrated a critical role of...

2003
Michael Fraser Brendan M. Leung Xiaojuan Yan Han C. Dan Jin Q. Cheng Benjamin K. Tsang

We established previously that X-linked inhibitor of apoptosis protein (Xiap) is a determinant of cisplatin (CDDP) resistance in human ovarian cancer cells and that down-regulation of Xiap sensitizes cells to CDDP in the presence of wild-type p53. Furthermore, Xiap up-regulates the phosphatidylinositol 3 -kinase/Akt pathway by increasing Akt phosphorylation. However, the precise relationships a...

Journal: :Anticancer research 2016
Maria Isabel Körber Anna Staribacher Ina Ratzenböck Günther Steger Robert M Mader

BACKGROUND Drug resistance to 5-fluorouracil (5-FU) is a major obstacle in colonic cancer treatment. Activation of nuclear factor-kappa B (NFκB), mitogen-activated protein kinase kinase kinase 8 (MAP3K8) and protein kinase B (AKT) is thought to protect cancer cells against therapy-induced cytotoxicity. MATERIALS AND METHODS Using cytotoxicity assays and immunoblotting, the impact of inhibitor...

2016
Paul Takam Kamga Giulio Bassi Adriana Cassaro Martina Midolo Mariano Di Trapani Alessandro Gatti Roberta Carusone Federica Resci Omar Perbellini Michele Gottardi Massimiliano Bonifacio Armel Hervé Nwabo Kamdje Achille Ambrosetti Mauro Krampera

Both preclinical and clinical investigations suggest that Notch signalling is critical for the development of many cancers and for their response to chemotherapy. We previously showed that Notch inhibition abrogates stromal-induced chemoresistance in lymphoid neoplasms. However, the role of Notch in acute myeloid leukemia (AML) and its contribution to the crosstalk between leukemia cells and bo...

2018
Lijuan Huang Ting Luan Yujin Chen Xin Bao Yinglong Huang Shi Fu Haifeng Wang Jiansong Wang

Mitochondria coordinated a lot of vital cellular processes of energy production and distribution. Change of mitochondrial functions has been implicated in cancer progression. The present study aims to investigate the involvement of mitochondria dynamics in LASS2 induced invasion and chemoresistance of bladder cancer cells. J82 and BIU87 cell lines were used for LASS2 plasmid transfection while ...

Journal: :International journal of oncology 2007
Suebwong Chuthapisith Robert Layfield Ian D Kerr Catherine Hughes Oleg Eremin

Chemoresistance is a poor prognostic factor in breast cancer and, thus, presents a significant clinical challenge. The mechanisms of chemoresistance involve multiple complex biological processes. This study aims to identify common contributory factors to chemoresistance in breast cancer by comparing protein expression profiles of chemosensitive MCF-7 breast cancer cells and cells resistant to t...

2014
Dong-Qin Chen Jia-Yuan Huang Bing Feng Ban-Zhou Pan Wei De Rui Wang Long-Bang Chen Jin Q. Cheng

The presence of cancer stem-like cells (CSCs) is one of the mechanisms responsible for chemoresistance that has been a major hindrance towards lung adenocarcinoma (LAD) treatment. Recently, we have identified microRNA (miR)-200b as a key regulator of chemoresistance in human docetaxel-resistant LAD cells. However, whether miR-200b has effects on regulating CSCs remains largely unclear and needs...

2014
Ercan Cacan Mourad W. Ali Nathaniel H. Boyd Shelley B. Hooks Susanna F. Greer

RGS10 is an important regulator of cell survival and chemoresistance in ovarian cancer. We recently showed that RGS10 transcript expression is suppressed during acquired chemoresistance in ovarian cancer. The suppression of RGS10 is due to DNA hypermethylation and histone deacetylation, two important mechanisms that contribute to silencing of tumor suppressor genes during cancer progression. He...

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