a simple and green chemical procedure was reported for the synthesis of dihydropyrimidinones from various aldehydes, ethyl acetoacetate and urea or thiourea using  holmium chloride as catalyst. the reactions were performed under solvent free conditions with ultrasound irradiation as the energy source. the advantages of this protocol include the excellent yield, operational simplicity, short tim...

Background A recently developed T2-preparation module for cardiac imaging at high field is insensitive to B0 and B1 inhomogeneity, cardiac motion and flow. Obtained T2 weighted images exhibit bright fat signal that can obscure the signal of myocardium and other muscles. Therefore, a chemical selective saturation (CHESS) is usually applied for fat suppression after the T2-preparation, e.g. in co...

The importance of bioconjugates within the field of chemistry drives the need for novel methodologies for their preparation. Well-defined and stable bioconjugates are easily accessible via the utilization of unnatural amino acids (UAAs). As such, we have synthesized and incorporated two new UAAs into green fluorescent protein, and optimized a novel Cadiot-Chodkiewicz bioconjugation, effectively...

Peptide thioesters are important tools for the total synthesis of proteins using native chemical ligation (NCL). Preparation of glycopeptide thioesters, that enable the assembly of homogeneously glycosylated proteins, is complicated by the perceived fragile nature of the sugar moiety. Herein, we demonstrate the compatibility of thioester formation via N→S acyl transfer with native N-glycopeptid...

We present a route for the preparation of cross-sectional TEM specimens of crystalline organic thin films which minimizes the mechanical, chemical and thermal load of the organic film during preparation and allows to take TEM images with molecular resolution. A typical example of a thin film of diindenoperylene capped with a thin layer of gold is shown to demonstrate the application of the tech...

The development of faster, simpler, inexpensive and more environmentally-friendly sample-preparation techniques is an important issue in chemical analysis. Recent research trends involve miniaturization of the traditional liquid-liquid-extraction principle by greatly reducing the acceptor-to-donor ratio. The current trend is towards simplification and miniaturization of sample preparation and d...

With the increasingly development of automobile, electronics, aviation, spaceflight and other industries, it has put forward higher and higher requirements on the quality of molybdenum powder metallurgy products. Therefore, it is required that molybdenum powder should have better performance in chemical composition, physical morphology, average particle size, particle size distribution, apparen...

In all but the simplest crystal structures, the identification of all relevant interactions between magnetic sites as well as the setup of magnetic model spaces, which are necessary for modeling macroscopic magnetism, are tedious and error-prone tasks. Here, we present a procedure to generate magnetic susceptibility versus temperature curves using only a crystal structure as input. The procedur...

Nanografted monolayers (NAMs) of DNA show novel physico-chemical properties that make them ideally suited for advanced biosensing applications. In comparison with alternative solid-phase techniques for diagnostic DNA detection, NAMs have the advantage of combining a small size with a high homogeneity of the DNA surface coverage. These two properties favour the extreme miniaturization and ultras...