BACKGROUND Thalassemia is a hereditary disorder requiring regular blood transfusion. PURPOSE To determine hearing sensitivity in transfusion-dependent thalassemics who were receiving desferioximine and on oral iron chelation (desferioximine) therapy. METHODS 26 patients with B-thelassemia in the age range of 5-22 years were enrolled in the thalassemia transfusion unit in the Advanced Pediat...

Significant mechanical stability is an essential feature shared by many elastomeric proteins, which function as molecular springs in a wide variety of biological machinery and biomaterials of superb mechanical properties. Despite the progress in understanding molecular determinants of mechanical stability, it remains challenging to rationally enhance the mechanical stability of proteins. Using ...

Phenolic compounds contribute to the antioxidant property of plants and efficient extraction plant phenolics could enhance its potential. Lagerstroemia speciosa (L.) Pers. has been investigated for pharmacological activities, but comparing activities derived from various parts a key role in developing natural antioxidants. This study was conducted standardize leaves, pods branches L. plant, fol...

The phenomena of displacement and immobilization of calcium ions by chelation is being studied in an increasing number of clinical states. Chelation therapy in hypercalcmmia (Holland et al., 1953; Spencer et al., 1956), calcium deposition in coronary arteries (Meltzer et al., 1960) and peripheral vessels (Clarke et al., 1960) and in skin (Muller et al., 1959), and in the treatment of digitalis ...

Chronic red blood cell transfusion can prevent many of the manifestations of sickle cell disease. The medical costs of chronic transfusion and management of associated side effects, especially iron overload, are considerable. This study was undertaken to evaluate the financial impact of chronic transfusion for stroke prevention in patients with sickle cell anemia. Outpatient charges pertaining ...

Alkenes have been discovered to be chelating groups to Zn(II), enforcing highly stereoselective additions of organozincs to β,γ-unsaturated ketones. 1H NMR studies and DFT calculations provide support for this surprising chelation mode. The results expand the range of coordinating groups for chelation-controlled carbonyl additions from heteroatom Lewis bases to simple C-C double bonds, broadeni...

The role of iron chelation therapy in myelodysplastic syndrome (MDS) remains controversial. Averting cardiac dysfunction in low-grade MDS patients who have sufficient longevity to experience deleterious cardiac effects of iron overload has been the major argument in favor of iron chelation. Although there is significant evidence showing the adverse impact of transfusion dependency on survival i...

BACKGROUND The purpose of this study was to assess the effectiveness of 2% ethylenediaminetetraacetic acid (EDTA) for the treatment of band-shaped keratopathy. METHODS We studied 24 eyes of 16 patients with band-shaped keratopathy who underwent EDTA chelation treatment from April 1, 2011 to December 31, 2012. We compared preoperative and 1 month postoperative logarithm of the minimum angle of...

Zhang Y., Zhao X.-H. (2013): Properties of casein hydrolysate as affected by plastein reaction in ethanol-water medium. Czech J. Food Sci., 31: 559–567. Casein hydrolysate with in vitro ACE-inhibitory activity of 44.4% at 0.3 mg/ml was generated from casein by Alcalase and modified by the Alcalase-catalysed plastein reaction in an ethanol-water medium. Eight treated hydrolysates were prepared u...

I read with interest the two case reports by Kwon et al. on ‘‘New Treatment for Band Keratopathy: Superficial lamellar Keratectomy, EDTA Chelation and Amniotic Membrane Transplantation’’ (1). In their article, they describe two cases of calcific band keratopathy (CBK) that were treated with a combination of EDTA chelation, superficial keratectomy and amniotic membrane transplantation. The autho...