Revascularization of bundles of skeletal muscle fibers transplanted into the cheek pouch of hamsters was examined previously by intravital and light microscopy. Some blood vessels survived the ischemia of transplantation and revascularization resulted from the growth of surviving vessels. We have now examined the cellular events of graft revascularization by electron microscopy (EM). Approximat...

The purpose of this study was to determine whether tannic acid elicits neurogenic plasma exudation from the oral mucosa in vivo and, if so, whether this response is transduced in part by thel-arginine-nitric oxide (NO) biosynthetic pathway. Using intravital microscopy, we found that suffusion of tannic acid elicits significant concentration-dependent leaky site formation and increase in clearan...

In isolated cell systems, nitric oxide synthase (NOS) activity is regulated by caveolin (CAV), a resident caveolae coat protein. Because little is known of this interaction in vivo, we tested whether NOS and caveolin are distributed together in the intact organism. Using immunohistochemistry, we investigated the localization of constitutive neuronal (nNOS) and endothelial (eNOS) enzyme isoforms...

This study is concerned with the behavior after transplantation of eleven human testicular cancers heterografted to the hamster cheek pouch. It was undertaken in an effort to establish an adequate supply of uniform and predictable tumor cells upon which investigations could be made into the biology of testicular cancer. Several reports are available concerning the be havior after heterotranspla...

OBJECTIVE To test the hypothesis that acupuncture on stomach 36 point (ST-36) reduces hypertension by activating nitric oxide synthase signaling mechanisms. METHODS The authors used the two-kidney, one-clip renal hypertension (2K1C) hamster model with electroacupuncture treatment. RESULTS Thirty-minute daily electroacupuncture treatment for 5 days reduced mean arterial pressure from 160.0 +...

The purpose of this study was to determine whether purified angiotensin I-converting enzyme (ACE) attenuates smokeless tobacco extract (STE)-induced increase in macromolecular efflux from the in situ oral mucosa. By using intravital microscopy, we found that suffusion of an aqueous extract of smokeless tobacco elicited significant concentration-dependent leaky site formation and increase in cle...

BACKGROUND AND OBJECTIVES The first objective of this study was to evaluate the performance of fluorescence spectroscopy for diagnosing pre-cancers in stratified squamous epithelial tissues in vivo using two different probe geometries with (1) overlapping versus (2) non-overlapping illumination and collection areas on the tissue surface. Probe (1) and probe (2) are preferentially sensitive to t...

cardiogenic shock. Circulation 45: 1097-1110, 1972 Weber KT, Janicki JS, Russell RO, Rackley CE: Identification of high risk subsets of acute myocardial infarction. Am J CardioMl: 197-203, 1978 Weisse AB, Saffa RS, Levinson GE, Jacobson WW Jr, Regan TJ: Left ventricular function during the early and late stages of scar formation following experimental myocardial infarction. Am Heart J 79: 370-3...

Genistein, an isoflavone present in soy at high concentrations and being considered the primary antitumor constituent in soy, has been known to be a natural anticancer agent in in vitro studies and experimental animal models. The present study was aimed to investigate the putative chemopreventive effect of genistein on oral carcinogenesis in hamster cheek pouch at the post-initiation stage, as ...

PURPOSE To test the possibility of obtaining a practical and stable model of hyperinsulinemia and hyperglycemia in hamsters, substituting the drinking water by 10% or 20% fructose solutions for a period of 2, 4, or 6 months. METHODS Male hamsters were divided into 3 main groups, further divided in 3 subgroups: Two months: Group Ia control (n = 51) received filtered water, Group Ib (n = 49) re...