This paper investigates the precision of three linearcomplexity type analyses for Java software: Class Hierarchy Analysis (CHA), Rapid Type Analysis (RTA) and Variable Type Analysis (VTA). Precision is measured relative to class targets. Class targets results are useful in the context of the receiver-classes criterion, which is an object-oriented testing strategy that aims to exercise every pos...

We have identified five independent allelic mutations, defining the gene cha-1, that result in decreased choline acetyltransferase (ChAT) activity in Caenorhabditis elegans. Four of the mutant alleles, when homozygous, lead to ChAT reductions of greater than 98%, as well as recessive phenotypes of uncoordinated behavior, small size, slow growth and resistance to cholinesterase inhibitors. Anima...

Our previous results showed that hyaluronan (HA) preserved human placenta-derived mesenchymal stem cells (PDMSC) in a slow cell cycling mode similar to quiescence, the pristine state of stem cells in vivo, and HA was found to prevent murine adipose-derived mesenchymal stem cells from senescence. Here, stable isotope labeling by amino acid in cell culture (SILAC) proteomic profiling was used to ...

BACKGROUND Carbonated hydroxyapatite (CHA) and related calcium phosphates have been studied for many years as implant materials due to their similarity with the mineral phase of bone. The main limitation of CHA ceramics as well as other bioactive materials is that they have poor mechanical proprieties. It is thought that the mechanical device can cause an increase in metabolic activity and bone...

MicroRNAs are small regulatory molecules that can be used as potential biomarkers of clinical diagnosis, and efforts have been directed towards the development of a simple, rapid, and sequence-selective analysis of microRNAs. Here, we report a simple and versatile colorimetric strategy for ultrasensitive and specific determination of microRNAs based on molecular beacon initiated strand displace...

Several porous calcium hydroxyapatite (HA) ceramics have been used clinically as bone substitutes, but most of them possessed few interpore connections, resulting in pathological fracture probably due to poor bone formation within the substitute. We recently developed a fully interconnected porous HA ceramic (IP-CHA) by adopting the 'foam-gel' technique. The IP-CHA had a three-dimensional struc...

Shuang-Huang-Lian (SHL), a famous traditional Chinese medicine recipe containing Lonicerae Japonicae Flos (LJF), Forsythiae Fructus, and Scutellariae Radix, is clinically used for the treatment of fever and acute upper respiratory tract infection. In this research, a comparative study was conducted to compare the pharmacokinetic difference of chlorogenic acid (ChA) after oral administration of ...

Objective: To evaluate the yield of guajillo pepper (CHG) and chile de árbol (CHA) grown in containers with coconut fiber substrate a hydroponic greenhouse system.Methodology: Four types chili peppers were tested: two CHG CHA peppers. The seeds from growing areas state San Luis Potosí (SLP), located Altiplano Central (high plateau region) Mexico: one Las Colonias, Salinas, other El Barril, Vill...

Consistent History Approach to quantum theory, introduced in explicit form by Griffiths [1], provides an extension of the interpretation of the formalism of quantum mechanics. While standard quantum theory is based on the concept of event, represented by a projection operator E of the Hilbert spaceH describing the system, CHA is based on the concept of history, which is a finite ordered sequenc...

Based on high-resolution UVES spectra we found that the radial velocity (RV) dispersion of nine of twelve known young bona fide and candidate brown dwarfs in the Cha I dark cloud is 2.0 kms, i.e. significantly smaller than the RV dispersion of T Tauri stars in Cha I (3.6 km/s) and only slightly larger than the dispersion of the surrounding molecular gas (1.2 km/s) (Mizuno et al. 1999). This res...