نتایج جستجو برای: cetp

تعداد نتایج: 1082  

Journal: :European heart journal 2008
Jakub J Regieli J Wouter Jukema Diederick E Grobbee John J P Kastelein Jan Albert Kuivenhoven Aeilko H Zwinderman Yolanda van der Graaf Michiel L Bots Pieter A Doevendans

AIMS Inhibition of cholesteryl ester transfer protein (CETP) increases HDL-cholesterol. However, its combination with statins may increase mortality by factors incompletely understood. We previously observed that patients with intrinsically low CETP levels (carriers of the TaqIB-B2 allele) may have less benefit from statin therapy, and here tested this pharmacogenetic hypothesis on long-term ou...

Journal: :Cardiovascular research 2008
Urbain Tchoua Wilissa D'Souza Nigora Mukhamedova Denise Blum Eric Niesor Jacques Mizrahi Cyrille Maugeais Dmitri Sviridov

AIMS Cholesteryl ester transfer protein (CETP) has a well-established role in lipoprotein metabolism, but the effect of its overexpression or inhibition on the efficiency of reverse cholesterol transport (RCT) is unclear. METHODS AND RESULTS Neither overexpression of CETP nor treatment with CETP inhibitor Torcetrapib of RAW 264.7 macrophages or HepG2 hepatocytes affected cholesterol efflux in...

Journal: :Diabetes 2005
Rindert de Vries Frank G Perton Geesje M Dallinga-Thie Arie M van Roon Bruce H R Wolffenbuttel Arie van Tol Robin P F Dullaart

We tested whether carotid artery intima-media thickness (IMT) is associated with plasma cholesteryl ester transfer (CET) and/or the plasma cholesteryl ester transfer protein (CETP) concentration in type 2 diabetic and control subjects. In 87 male and female subjects with type 2 diabetes (nonsmokers, no insulin or lipid-lowering drug treatment) and 82 control subjects, IMT, plasma CET, CETP mass...

Journal: :Journal of lipid research 2001
J C Escolà-Gil J Julve A Marzal-Casacuberta J Ordóñez-Llanos F González-Sastre F Blanco-Vaca

Apolipoprotein (apo)A-II is a major high density lipoprotein (HDL) protein; however, its role in lipoprotein metabolism is largely unknown. Transgenic (Tg) mice that overexpress human apoA-II present functional lecithin: cholesterol acyltransferase deficiency, HDL deficiency, hypertriglyceridemia and, when fed an atherogenic diet, increased non-HDL cholesterol and increased susceptibility to at...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2007
Alan R Tall Laurent Yvan-Charvet Nan Wang

Hopes have been running high that treatments aimed at raising HDL levels would soon help to reduce the large burden of cardiovascular disease that remains in patients at high risk of CHD who are now treated with statins. The unexpected and premature termination of the ILLUMINATE study has dashed those hopes. This study was designed to determine the clinical outcome of raising HDL by treatment w...

Journal: :Brazilian Journal of Pharmaceutical Sciences 2022

Dyslipidemia is an abnormal lipid profile associated with many common diseases, including coronary heart disease and atherosclerosis. Cholesteryl ester transfer protein (CETP) a hydrophobic plasma glycoprotein that responsible for the of cholesteryl from high-density lipoprotein athero-protective particles to pro-atherogenic very low-density particles. The requirement new CETP inhibitors, which...

Journal: :Circulation 2010
Reecha Sofat Aroon D Hingorani Liam Smeeth Steve E Humphries Philippa J Talmud Jackie Cooper Tina Shah Manjinder S Sandhu Sally L Ricketts S Matthijs Boekholdt Nicholas Wareham Kay Tee Khaw Meena Kumari Mika Kivimaki Michael Marmot Folkert W Asselbergs Pim van der Harst Robin P F Dullaart Gerjan Navis Dirk J van Veldhuisen Wiek H Van Gilst John F Thompson Pamela McCaskie Lyle J Palmer Marcello Arca Fabiana Quagliarini Carlo Gaudio François Cambien Viviane Nicaud Odette Poirer Vilmundur Gudnason Aaron Isaacs Jacqueline C M Witteman Cornelia M van Duijn Michael Pencina Ramachandran S Vasan Ralph B D'Agostino Jose Ordovas Tricia Y Li Sakari Kakko Heikki Kauma Markku J Savolainen Y Antero Kesäniemi Anton Sandhofer Bernhard Paulweber Jose V Sorli Akimoto Goto Shinji Yokoyama Kenji Okumura Benjamin D Horne Chris Packard Dilys Freeman Ian Ford Naveed Sattar Valerie McCormack Debbie A Lawlor Shah Ebrahim George Davey Smith John J P Kastelein John Deanfield Juan P Casas

BACKGROUND Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL) cholesterol, but torcetrapib, the first-in-class inhibitor tested in a large outcome trial, caused an unexpected blood pressure elevation and increased cardiovascular events. Whether the hypertensive effect resulted from CETP inhibition or an off-target action of torcetrapib has been debated. We...

ژورنال: :مجله دانشکده پزشکی دانشگاه علوم پزشکی تهران 0
عسگر برخورداری barkhordari asgar department of clinical biochemistry, hamadan university of medical sciences, hamadan, iran.گروه بیوشیمی و تغذیه، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی همدان، دانشکده پزشکی تقی حسن زاده hassanzadeh taghi department of clinical biochemistry, school of medicine, hamadan university of medical sciences, shahid fahmideh st. hamadan, iran. tel: +98 -811- 8380462همدان، خیابان شهید فهمیده، روبه روی پارک مردم، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی همدان، دانشکده پزشکی، گروه بیوشیمی، تلفن: 8380462-0811 مسعود سعیدی جم saidijam masoud research center for molecular medicines, hamadan university of medical sciences, hamadan, iran.مرکز تحقیقات پزشکی مولکولی، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی همدان، دانشکده پزشکی رسول اسماعیلی esmaeili rasoul student's research committeeکمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی همدان، دانشکده پزشکی مکس پائولی paoli max school of pharmacy and center for biomolecular science, university of nottingham, nottingham, uk.مرکز علوم بیوملکولی، دانشکده داروسازی، دانشگاه ناتینگهام، بریتانیا

زمینه و هدف : هیپرکلسترولمی یک فاکتور خطر اصلی برای بیماری های قلبی عروقی، آترواسکلروز و پانکراتیت می باشد. پلی مورفیسم های ژن کلسترول استر ترانسفر پروتیین می تواند با تغییراتی در میزان لیپیدها همراه باشد. در این مطالعه ارتباط پلی مورفیسم d442g ژن کلسترول استر ترانسفر پروتیین (cetp) را با الگوی لیپیدی و فعالیت cetp در بیماران هیپرکلسترولمی و گروه شاهد بررسی نمودیم. روش بررسی: در یک مطالعه مورد-...

2017
Belinda A Di Bartolo Stephen J Nicholls

Cholesteryl ester transfer protein (CETP) facilitates movement of esterified cholesterol between high-density lipoproteins (HDLs) and apolipoprotein B-containing lipoproteins. By virtue of their ability to raise HDL cholesterol and lower low-density lipoprotein cholesterol, pharmacological inhibitors of CETP have received considerable attention as potential new agents in cardiovascular preventi...

Journal: :Jordan Journal of Pharmaceutical Sciences 2023

Cardiovascular diseases, as coronary heart disease, failure, and hypertension are the first leading cause of death in United States third globally. CETP is a glycoprotein excreted mainly from liver found plasma. Normal plasma concentration 1-4 µg/ml, while ratio increased 70-80% dyslipidemic patients. There growing need for new inhibitors which encourages us to conduct this research. In work, s...

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