The initial host response to viral infection occurs after Toll-like receptors (TLRs) on dendritic cells (DC) are stimulated by viral nucleic acids (double-stranded RNA, single-stranded RNA) and alpha interferon (IFN-alpha) and IFN-beta are produced. We hypothesized that pharmacologic induction of innate antiviral responses in the cervicovaginal mucosa by topical application of TLR agonists prio...

Resumo Objetivo Avaliar duas técnicas de coleta cervicovaginal à adequabilidade da amostra e aos demais achados do laudo colpocitopatológico. Métodos O estudo foi realizado no período setembro 2018 a julho 2019, em um centro saúde-escola, localizado município Fortaleza – Ceará. A composta por 365 mulheres divididas aleatoriamente, sendo 184 participantes Grupo Controle (técnica na qual o esfreg...

OBJECTIVE: To investigate the association of bacterial vaginosis and skin disorders in patients with autoimmune antibody positivity.STUDY DESIGN: This retrospective study consisted 80 positivity. All were evaluated for presence disorders. Cervicovaginal smears used definitive diagnosis vaginosis. RESULT: We found 13.75% (11/80) cases. 1 (9.1%) 10 (90.9%) cases had positive negative groups respe...

Purpose: Imiquimod is a Toll-like receptor 7 agonist used topically to treat external genital warts and basal cell carcinoma. We examined the combination of topical imiquimod with intramuscular administration of CRT/E7, a therapeutic human papillomavirus (HPV) vaccine comprised of a naked DNA vector expressing calreticulin fused to HPV16 E7. Experimental Design: Using an orthotopic HPV16 E6/E7þ...

BACKGROUND This study investigated gp120-binding antibody and neutralizing activity, at the gingival- and cervical-mucosal levels, in response to a bivalent gp120 candidate vaccine. METHODS Women who met the study's inclusion criteria for documented high-risk behaviors participated in a nested substudy of the multicenter phase 3 trial of human immunodeficiency virus (HIV)-vaccine efficacy, VA...

The purpose of this study was to evaluate the relationship between the levels of βhCG cervicovaginal secretions and preterm delivery. A cross-sectional analysis was used and cerevicovaginal secretion specimens were obtained from women in their 24th-36th weeks (every 6 days) of pregnancy who presented the pregnancy clinic with preterm labor manifestations. Frozen samples (at -20°C) were assayed ...

OBJECTIVES To determine whether human chorionic gonadotropin (hCG) detected in cervicovaginal secretions of patients with symptoms suggestive of preterm labor is a predictor of preterm birth. METHODS Women presenting to labor and delivery with symptoms of preterm labor were invited to participate. After collecting secretions with a cotton-tipped applicator from the posterior fornix and endoce...

BACKGROUND The purpose of our study was to determine the prevalence and significance of psammoma bodies (PBs) in the cervicovaginal smears of the screening population of Trento district (Italy), with the description of the cytological presentation of an asymptomatic bilateral ovarian psammocarcinoma. METHODS From 1993 to 2006, women with PBs detected on consecutively screened cervical smears ...

Vitamin D binding protein (VDBP) has previously been identified in the amniotic fluid and cervicovaginal fluid (CVF) of pregnant women. The biological functions of VDBP include acting as a carrier protein for vitamin D metabolites, the clearance of actin that is released during tissue injury and the augmentation of the pro-inflammatory response. This longitudinal observational study was conduct...