Cervical cancer (CC) is the second leading cause of cancer morbidity and mortality around the world. The development of CC involves major factors as the infection with high-risk human papillomavirus (HPV), estrogen imbalance, high sexual activities and cigarette smoking. Knowledge of the categories of risk factors is used to develop prevention strategies for CC, of major interest being the meta...

W orldwide, an estimated 493,243, cases of invasive cervical cancer (ICC) occur each year and 273,505 women die of the disease. There is a global disparity in the incidence of cervical cancer, with the burden of cases occurring in less developed countries (83%), where effective cervical cancer screening and treatment services have often been difficult to implement (Fig 1). In more developed cou...

BACKGROUND Cervical cancer (CC) treatments impact quality of life (QoL) and sexual function (SF) of survivors. Treatment options to reduce sexual dysfunction are limited. The aim of this study was to assess the effectiveness of ospemifene in CC survivors with clinical signs and symptoms of vulvovaginal atrophy (VVA) focusing on their QoL and SF. MATERIALS AND METHODS Fifty-two patients with p...

Cervical cancer (CC) still remains a common and deadly malignancy among females in developing countries. More accurate and reliable diagnostic methods/biomarkers should be discovered. In this study, we performed a comprehensive analysis of metabolomics (285 samples) and transcriptomics (52 samples) on the potential diagnostic implication and metabolic characteristic description in cervical canc...

Abstract Background Epiplakin1 (Eppk1) is part of epidermal growth factor (EGF) signal and takes in reorganization cytoskeleton cell proliferation. However, the role Eppk1 cervical cancer (CC) remains unknown. Methods To express KLF5 their correlation, we used RNA-sequence, RT-qPCR, TCGA database immunofluorescence staining vitro different pathological tissues. In CC lines, tested adenovirus-me...

Objective: Cervical cancer (CC) screening ends at the age of 65 in Turkey, as many countries. However, about a quarter CCs
 occurs women over 65. Persistent high-risk human papillomavirus(HR-HPV) infection is most important factor
 leading to CC. In this study, we aimed investigate prevalence cervical HR-HPV and cytological abnormalities Turkish
 aged over.
 Patients Methods...

background: the sentinel lymph node (sln) is defined as the first chain node in the lymphatic basin that receives primary lymphatic flow. if the sln is negative for metastatic disease, then other nodes are expected to be disease-free. sln techniques have been extensively applied in the staging and treatment of many tumors, including melanoma, breast and vulvar cancers. this study aims to evalua...

Introduction: In Serbia, cervical cancer (CC) is the second most common cancer, after breast The Papanicolaou test used for early detection of cancer. Motivational factors and attitudes women about benefits screening can affect rate participation in it. aim research was to examine whether there a connection between women's motivational their CC. Methods: This cross-sectional study included 300 ...

To assess the associations of P16INK4a methylation status with low-grade squamous intra-epithelial lesion (LSIL), high-grade squamous intra-epithelial lesion (HSIL), cervical cancer (CC) and their clinicopathological features, a meta-analysis with 29 eligible studies was conducted. Pooled odds ratios (ORs) with their 95% confidence intervals (CIs) were estimated to assess the strength of the as...

background and objectives : human papillomavirus (hpv) infection is a major risk factor for adenocarcinoma of the cervix. the high-risk types of the virus such as hpv16 and hpv18, which possess the e6 and e7 oncogenes, are responsible for approximately 50% of all cervical cancers. a rapid, sensitive and specific test has been proposed for detection of hpv to improve cervical cancer screening pr...