نتایج جستجو برای: cerebral dopamine neurotrophic factor cdnf
تعداد نتایج: 1055187 فیلتر نتایج به سال:
OF DISSERTATION NIGROSTRIATAL DOPAMINE-NEURON FUNCTION FROM NEUROTROPHIC-LIKE PEPTIDE TREATMENT AND NEUROTROPHIC FACTOR DEPLETION Trophic factors have shown great promise in their potential to treat neurological disease. In particular, glial cell line-derived neurotrophic factor (GDNF) has been identified as a potent neurotrophic factor for midbrain dopamine (DA) neurons in the substantia nigra...
Glial-cell-line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for adult nigral dopamine neurons in vivo. GDNF has both protective and restorative effects on the nigro-striatal dopaminergic (DA) system in animal models of Parkinson disease. Appropriate administration of this factor is essential for the success of its clinical application. Since it cannot cross the blood-brai...
EFFECT OF LOW ENDOGENOUS BRAIN-DERIVED NEUROTROPHIC FACTORLEVELS ON STRIATAL DOPAMINE DYNAMICSbyFRANCIS KABUI MAINADecember 2011Advisor: Dr. Tiffany A. MathewsMajor: Chemistry (Analytical)Degree: Doctor of PhilosophyMany neurological diseases and disorders are a result of alterations withneurotransmitters, neuromodulators, and/or proteins. Specifically, one p...
Bone marrow stromal cells (MSCs) have the capability under specific conditions of differentiating into various cell types such as osteocytes, chondrocytes, and adipocytes. Here we demonstrate a highly efficient and specific induction of cells with neuronal characteristics, without glial differentiation, from both rat and human MSCs using gene transfection with Notch intracellular domain (NICD) ...
Two research areas that could benefit from a greater focus on the role of the reward pathway are maternal depression and maternal addiction. Both depression and addiction in mothers are mediated by deficiencies in the reward pathway and represent substantial risks to the health of offspring and future generations. This targeted review discusses maternal reward deficits in depressed and addicted...
Abbreviations: GDNF, Glial cell line-derived neurotrophic factor; GDNFOS, GDNF opposite strand; BDNFOS, BDNF opposite strand; NAT, natural antisense transcripts; AD, Alzheimer’s disease; HD, Huntington’s disease; CON, control; MTG, middle temporal gyrus; EST, expressed sequence tags; UTR, un-translated region of mRNA; RT-qPCR, reverse transcription – quantitative polymerase chain reaction; MGB,...
Although glial cell-line derived neurotrophic factor (GDNF) acts as a potent survival factor for dopaminergic neurons, it is not known whether GDNF can directly alter dopamine synthesis. Tyrosine hydroxylase (TH) is the rate-limiting enzyme for dopamine biosynthesis, and its activity is regulated by phosphorylation on three seryl residues: Ser-19, Ser-31, and Ser-40. Using a TH-expressing human...
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