Diffuse intrinsic pontine gliomas (DIPGs) are a fairly common pediatric brain tumor, and children with these tumors have a dismal prognosis. They generally are diagnosed within the first decade of life, and due to their location within the pons, these tumors are not surgically resectable. The median survival for children with DIPGs is less than 1 year, in spite of decades of clinical trial deve...

This brilliant and sumptuously produced monograph deals with 29 histologically certified cases of tumours of the cerebello-pontile angle, involving the VIII (acoustic) nerve. It illustrates' the extreme specialisation that has taken place in cerebral surgery of recent years, largely the work of the late Sir Victor Horsley at the National Hospital for Paralysed and Epileptic in London. Dr. Harve...

Medulloblastoma is the most common malignant and uncontrollable childhood brain tumor. This tumor is observed in patients of all ages, reaches a peak in children between 3 and 9 years old, and it is also the most common malignant cerebellar tumor in infants. It accounts for 1% to 2% of all brain tumors in adults. By definition, medulloblastomas arise in the posterior fossa, but histologically s...

Inadequate tumor uptake of the vascular endothelial growth factor antibody bevacizumab could explain lack of effect in diffuse intrinsic pontine glioma. Methods: By combining data from a PET imaging study using 89Zr-labeled bevacizumab and an autopsy study, a 1-on-1 analysis of multiregional in vivo and ex vivo 89Zr-bevacizumab uptake, tumor histology, and vascular morphology in a diffuse intri...

Lesions of the cerebellum lead to motor and non-motor deficits by influencing cerebral cortex activity via cerebello-cortical circuits. It remains unknown whether the cerebello-cortical "disconnection" underlies motor and non-motor impairments both in the parkinsonian variant of multiple system atrophy (MSA-P) and Parkinson's disease (PD). In this study, we investigated both the functional and ...

Cerebral localization of the larval form of Echinococcus granulosus is a rare occurrence (1-4% of cases of hydatidosis) [1 ] , and usually produces solitary large unilocular (hydatid) cysts located in the supratentorial compartment [2-4]. We report the plain and contrast-enhanced MR appearance of a histologically proved pontine hydatid cyst that was adjacent to a multicystic acoustic neurinoma ...

Brain tumors are common solid pediatric malignancies and the main reason for cancer-related death in setting. Recently, evidence has revealed that noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long ncRNAs (lncRNAs), circular (circRNAs), play a critical role brain tumor development progression. Therefore, this review article, we describe functions molecular mechanisms of multiple types ...

Patients with diffuse intrinsic pontine gliomas (DIPG) have a poor prognosis. Although DIPG constitute only 10-15% of all pediatric brain tumors, they are the main cause of death in this group. Despite 26 clinical trials in newly diagnosed DIPG in the past 5years (including several targeted agents), there is no clear improvement in prognosis. However, knowledge on DIPG biology is increasing, ma...

BACKGROUND Diffuse intrinsic pontine gliomas represent a unique subtype of primary brain tumors occuring in a specific location and age. Their growth demonstrates early invasion and, following diagnosis, rapid growth not responsive to common therapies. Until recently, the genetic and cellular basis of these tumors was unknown. Genetic evidence implicates mutations in the histone genes in the or...

Brain tumors represent the most common solid neoplasm in children and second most common pediatric malignancy overall, following leukemia. Outside of infancy, the majority of primary childhood brain tumors occur in the infratentorial compartment and include medulloblastoma, juvenile pilocytic astrocytoma (JPA), ependymoma, and brainstem/ pontine glioma; atypical teratoid rhabdoid tumor (ATRT) i...