This study compares the inhibitory effect of ceftizoxime with that of penicillin G, chloramphenicol, cephalothin, cephalexin and cefzoline on Klebsiella pneumoniae, Proteus mirabilis, pseudomonas ruginosa, staphylococcus aureus, staphylococcus epidermidis, staphylococcus saprophyticus and Escherichia coli. The in vitro inhibitory effect of ceftizoxime on P. mirabilis, P. Aeruginosa, S.prophytic...

Buffered cephalothin, cefamandole, and cephapirin were compared with respect to their tendency to produce phlebitis. Two grams of each agent was administered every 6 h for 4 days to 12 healthy volunteers in a double-blind crossover fashion. Approximately 50% of intravenous sites developed mild (grade 1) phlebitis and 25% developed moderate (grade 2) phlebitis. The frequency of grade 1 inflammat...

The in vitro activity of HR756, a new semisynthetic cephalosporin, was compared with the activities of cephalothin, cefoxitin, and cefamandole against 1,535 isolates of gram-positive and gram-negative bacteria. HR756 was less active than cephalothin and cefamandole and twofold more active than cefoxitin against Staphylococcus. All four of the antibiotics were inactive against the enterococcus g...

The effect of four antibiotics (amikacin, clindamycin, cephalothin and vancomycin) was investigated considering that bacterial infection in fibroblasts cultures is a very frequent event. The investigation included the effect of the antibiotics on fibroblast growth and on the activity of the enzyme glucocerebrosidase. The antibiotics were added to the fibroblast cultures and cell growth was eval...

Strains (115) of Bacteroides fragilis were identified at the subspecific level and were tested for susceptibility to ampicillin, cephalothin, chloramphenicol, clindamycin, penicillin, and tetracycline using an agar dilution technique. We tested the following strains: B. fragilis subsp. distasonis, 12; B. fragilis subsp. fragilis, 39; B. fragilis subsp. ovatus, 10; B. fragilis subsp. thetaiotaom...