This research article presents the Quality by Design (QbD)-finalised conditions for a method that uses liquid chromatography-tandem mass spectrometry for the determination of concentration of enzalutamide (ENZ), an atypical anticancer drug, in a drug formulation and in spiked plasma samples. Critical process attributes (CPA) considered to be the influential parameters in separation, identificat...

a chemically modified carbon paste electrode with multiwall carbon nanotube (mwcnt) was prepared and used as a sensor for cu2+ ion. the unique chemical and physical properties of cnt have paved the way  to  new  and  improved  sensing  devices.  a  central  composite chemometrics  design  was  applied  for  multivariate  optimization  of the  effects  of  three  significant  parameters  (graphi...

Objective: The recent study's objective was to optimize and formulate a controlled-release gastro-retentive floating tablet of RG using central composite design, which provides continuous release Repaglinide for up 24 h. Methods: (RG-GRF Tablet) prepared by direct compression method. optimization carried out three-factor three-level Central Composite design. amount Eudragit RSPO (A), HPMC K-100...

Enhanced ganoderic acid Me (GA-Me, an important anti-tumor triterpene) yield was attained with the medicinal fungus Ganoderma lucidum using response surface methodology (RSM). Interactions were studied with three variables, viz. glucose, peptone and culture time using a Central Composite Design (CCD). The CCD contains a total of 20 experiments with the first 14 experiments organized in a fract...

this paper describes optimization method that combines the plackett-burman design, a factorial design and the response surface method, which were used to optimize the medium for the production of l-asparaginase by serratia marcescens sb08. four medium factors, from out of 11 medium factors, were screened by plackett-burman design experiments and subsequent optimization process to find out the o...

low-fat butter is water in oil emulsion comprising a continuous fat phase including butter, emulsifiers and colorants and also a dispersed aqueous phase including water, stabilizers and proteins. in this research, by using protein components especially full-fat soy flour, a product were produced which has extreme similarity to ordinary butter and also has good organoleptic properties. water : b...

heavy metals removal from polluted wastewater is one of the major concerns due to their harmful effectson human health and the environment. the aim of this study is to absorb cu2+ and co+2 ions from wastewater by means of a synthesized magnetite bentonite nono - adsorbent. initially, nano- adsorbent was produced by coprecipitation techniques. then, the resultant material was analyzed and evalua...

Oil palm empty fruit bunch (OPEFB) is an abundant waste that commonly incinerated, causing environmental pollution. In this study, alternative management approach was investigated to produce value-added syngas from OPEFB using solar steam gasification. The three operating variables were temperature (1100–1300 °C), H2O/OPEFB molar ratio (1.7–2.9), and flowrate (0.8–1.8 g/min). Central composite ...

An active strain, isolated from soil of Chhattisgarh, India, showed broad-spectrum antimicrobial activity against various pathogenic bacteria and fungi in glucose soybean meal broth. Strain was characterized as Streptomyces hygroscopicus MTCC 4003 based on 16S rRNA sequencing from Microbial Type culture Collection (MTCC), IMTECH, Chandigarh, India. Identification of the purified antimicrobial c...