Missing data are a frequent problem in cost-effectiveness analysis (CEA) within a randomised controlled trial. Inappropriate methods to handle missing data can lead to misleading results and ultimately can affect the decision of whether an intervention is good value for money. This article provides practical guidance on how to handle missing data in within-trial CEAs following a principled appr...

The parent allenediazonium monocation H2C[double bond]C[double bond]CH(N2+) and ten of its substituted derivatives XYC[double bond]C[double bond]C(Z)N2+ (with F, CF3, Me, OMe, and Me2N as substituents) were studied by DFT at the B3LYP/6-31++G** level. Except for the Me2N-substituted derivative that forms a monocation-N2 complex, structurally intact allenediazonium ions were obtained as minima i...

Let X be a reduced closed scheme in P and let IX be its saturated defining ideal. As a generalization of property Np due to Green-Larzarsfeld, we say that X satisfies property N2,p if IX has only the simplest linear syzygies up to p-th step. When p = 1, then IX is generated by quadrics. Recently, many interesting geometric results have been proved for projective varieties with property N2,p (se...