To investigate the effects of the two-pore-domain potassium (K2P) channel TASK-3 in a syngeneic murine model for malignant glioma. Malignant or high-grade glioma (WHO grade III and IV) are the most common and most aggressive primary brain tumors in adults. Despite aggressive multimodal therapy, the outcome of patients with malignant glioma remains poor. However, recent phase I and II trials hav...

conclusions our findings showed that the treatment of flaps with bm-msc and aam transplantations significantly promoted flap survival compared to a control group. the viability of the flap was improved by combining bm-mscs with aam matrix scaffolds. materials and methods bm-mscs and aams were transplanted into subcutaneous tissue in the flap area. on the 7th postoperative day, the surviving fla...

Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...

introduction: the use of cord stem cells, as a cell source for bone marrow reconstruction in patient under hematopoietic stem cell transplantation is enhancing. the amount of cd34+cells collected from cord blood compared to peripheral blood and bone marrow are less, but their collectionprocesure is easier. delay in freezing has negative effect on cells surveillance and reduce their ability in t...

introduction: satellite cells are known as the main regenerative cell type in skeletal muscles. our study established a modified digestion and preplating method for the isolation of slow or weak adherent cells for the enrichment of satellite cells. low-survival rate of these primary stem cells prompted us to address whether cell culture medium substitution might change cell viability status. me...

Background: Evaluation of cell viability is momentous in pharmacologic and oncological research. Cell viability evaluation determines cell sensitivity and consequently treatment outcome. Various methods are available to determine cell survival. Each of these methods evaluates different endpoints. Accordingly, determining the correlation between these methods is important. In this study, in orde...

The aim of this study was to evaluate antitumour activity of the roots of Hibiscus tiliaceus Linn. against Dalton’s Ascitic Lymphoma (DAL) in Swiss albino mice. A significant enhancement of mean survival time (MST) of H. tiliaceus treated tumour bearing mice was found with respect to control group. H. tiliaceus treatment was found to enhance peritoneal cell counts. When these H. ti...

Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...