background: sickle cell disease occurs due to a mutation in β chains and the substitution of valine instead of glutamate in the sixth position of the ß-chain that causes polymerization and vascular blockage. the aim of this study was to compare the serum c, s proteins and factor v leiden between sickle cell patients and the control group. materials and methods: in this case-control study, perfo...

objective(s): activation of acid-sensing ion channel 1a (asic1a) is responsible for tissue injury caused by acidosis in nervous systems. but its physiological and pathological roles in nucleus pulposus cells (npcs) are unclear. the aim of this study is to investigate whether asic1a regulates the survival of npcs in the acidic environment of degenerated discs. materials and methods: npcs were is...

pneumococcal autolysins are enzymes involved in cell wall turnover and cellular division physiologically. they have been found to be involved in the pneumococcus pathogenesis. the aim of this study was to identify the autolytic activity of spr1754 as a novel protein of streptococcus pneumoniae . moreover, the binding of the recombinant protein to plasma proteins was also determined. the spr1754...

this paper reviews recent strategies used for increasing specific yield and productivity in high cell density cultures. high cell density cultures offer an efficient means for the economical production of recombinant proteins. however, there are still some challenges associated with high cell density cultivation (hcdc) techniques. a variety of strategies in several aspects including host design...

abstract ethanol has a vast consumption around the world. many researches confirmed some adverse effect of this component on human health. in addition, recent studies showed significant alteration in both cellular population, and protein profile of human foreskin fibroblast cell line (hfff2) in the specific dosage of ethanol. here, the role and interaction of some proteins (characterized by sig...

Background: The expression of bio-therapeutic proteins in mammalian cells, such as CHO, attains high homogeneity related to post-translational modifications. Although CHO remains the most popular cell line for bestselling biotherapeutic proteins on the market, there are still drawbacks such as expensive culture media, long time line, and high drug cost. Recently, researches on a novel Leishmani...

Shark cartilage is considered as a natural dietary supplement consisting of anti-angiogenic, immunostimulatory, and anti-inflammatory characteristics. Therefore, this study was designed to inspect the possibility that whitecheek shark (Carcharhinus dussumieri) cartilage proteins motivate expression of NKG2D, CXCR3, NKP46, and NKP44 receptors on natural killer cells and their activities against ...