細胞発生力顕微鏡は，細胞の明視野画像を得ることにより，その細胞が発生する力（traction force）を定量的に予測することができる．本技術は，従来のtraction force測定法に比べて圧倒的に高いスループットを実現しているが故に，定量化の難しいメカノバイオロジー研究において新しい展開を拓きうる．

background: occupational and environmental exposures mostly represent mixtures of genotoxic agents, whereas the specificity of biomarker measurements varies widely. exploration of correlations among biomarkers contributes to the further progress of molecular cancer epidemiology and to the selection of the optimal biomarkers for the investigation of human exposure to carcinogens. the aim of this...

Inspired by massive intermediate filament (IF) reorganization in superstretched epithelia, we examine computationally the principles controlling mechanics of a set entangled filaments whose ends slide on cell boundary. We identify an entanglement metric and threshold beyond which random loose networks respond non-affinely nonlinearly to stretch self-organizing into structurally optimal star-sha...

Hippo effectors YAP/TAZ act as on-off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway are under the control of focal adhesions (FAs). Here we unveil the molecular mechanism by which cell spreading and RhoA GTPase activity contro...