Cefepime/sulbactam is a combined antibiotic consisting of the 4 th generation cephalosporin cefepime and beta-lactamase inhibitor sulbactam in 1:1 ratio. was developed Russia 2006, it had passed preclinical clinical studies, approved for medical use, has been produced since 2019. Cefepime wide spectrum antimicrobial activity against gram-positive gram-negative microorganisms, adds two clinicall...

Aeromonas hydrophila was isolated from 12 (5.3%) of 225 patients with acute gastroenteritis.The present study was determined the virulence of A. hydrophila obtained from patients with diarrhea, among 12 A. hydrophila isolates obtained from stool, 83.3%, 91.6%, 83.3%, 75%, 75%, 50% produced β-haemolysin, protease ,phospholipase, DNase, slime(viscous glycoconjugate material), and have the adhesio...

JMD Dear Sir, Cefepime is a commonly prescribed antibiotic, but the frequency and incidence of its neurotoxicity are unknown. 2 Early discontinuation after the development of neurotoxicity is crucial to recovery and to reducing morbidity and mortality. 3 The pathophysiology of cefepime-induced myoclonus is unknown. Much of the current literature does not describe debilitating jaw myoclonus. 1,3...

We read with interest the letter from May et al. recently published in Critical Care [1]. The authors suggest that overdosing of β-lactams in 108 critically ill patients receiving renal replacement therapy may not be associated with neurotoxicity. We agree that adequate plasmatic levels of β-lactams in critically ill patients with sepsis should be a primary goal and that under-dosing may put th...

Cefepime is a fourth-generation cephalosporin that is frequently used in a wide array of infections. Since approval for use, concerns have been raised due to adverse effects including seizures, encephalopathy and myoclonus especially if renal dysfunction is present. Despite having appropriate renal dose adjustments, cases have been found with adverse neurological effects. On this occasion, we p...

We investigated the in vitro susceptibilities of 23 Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime by utilizing the Etest. The MICs ranged from 0.094 microg/ml to 0.75 microg/ml, 0.094 microg/ml to 1.5 microg/ml, and 1 microg/ml to 12 microg/ml for ertapenem, meropenem, and cefepime, respectively. Based on our excellent in vitro carbapenem susceptibility resul...

The pharmacokinetics of cefepime following administration of a single 2-g dose were evaluated for 12 adult patients with thermal burn injury and suspected or documented infection. Serial blood and urine samples for cefepime concentration determination were obtained for 24 h following drug administration. Serum and urine cefepime concentrations were determined by high-performance liquid chromato...

BACKGROUND  AmpC β-lactamase-producing organisms are associated with significant morbidity and mortality. Induction of resistance to third-generation cephalosporins after exposure to these agents complicates treatment options and carbapenems are considered optimal therapy. The role of cefepime, however, remains unclear. Our objective was to compare clinical outcomes for patients receiving cefep...