BACKGROUND Proliferation of oval cells, the bipotent precursor cells of the liver, requires impeded proliferation and loss of hepatocytes as well as a specific micro-environment, provided by adjacent sinusoidal cells of liver. Despite their immense importance for triggering the oval cell response, cells of hepatic sinusoids are rarely investigated. To elucidate the response of sinusoidal liver ...

Evidence suggests that infusional therapy is a more effective means for administering cytotoxic therapy than intravenous bolus therapy for lymphoma and offers greater potential for therapeutic synergy with rituximab, which has a long half-life. We pooled the results of 3 prospective phase 2 trials evaluating rituximab in combination with 96-hour infusion of cyclophosphamide (187.5-200 mg/m2 per...

As far as we know, there is no decoding algorithm of any binary self-dual [40, 20, 8] code except for the syndrome decoding applied to the code directly. This syndrome decoding for a binary self-dual [40, 20, 8] code is not efficient in the sense that it cannot be done by hand due to a large syndrome table. The purpose of this paper is to give two new efficient decoding algorithms for an extrem...

Open source projects are characterized by their distributed developers, openness, and use of a community-based development process. Successful open source projects such as Apache, Linux, and PHP have a web-based Collaborative Development Environment (CDE) that provides source code repository access, knowledge management, discussion lists, bug tracking, and user support. Distributed software dev...

Young female mice fed a choline-deficient, ethionine-supplemented (CDE) diet for 24 h develop hemorrhagic pancreatic necrosis with a 5-day mortality rate of approximately 50%. At the end of the diet administration, the in vivo discharge of digestive enzymes is blocked, images of exocytosis and luminal membrane recycling disappear, and zymogen granules accumulate within acinar cells. The general...

Classical tools for supporting software engineering teams (collaborative development environment, CDE) are designed to support one team during the development of a product. Often the required data sources or experts reside outside of the internal project team and thus not provided by these CDEs. This paper describes an approach for a community-embedded CDE (CCDE), which is capable of handling m...

Improving management of inpatients with diabetes undergoing vascular surgery requires collaboration among many health care practitioners. This article describes a performance improvement project that implemented two evidence-based algorithmic order sets to guide perioperative glucose management for diabetic patients undergoing vascular procedures and utilized a certified diabetes educator (CDE)...

We introduce Fisher consistency in the sense of unbiasedness as a criterion to distinguish potentially suitable and unsuitable estimators of prior class probabilities in test datasets under prior probability and more general dataset shift. The usefulness of this unbiasedness concept is demonstrated with three examples of classifiers used for quantification: Adjusted Classify & Count, EM-algorit...