BACKGROUND Extra-nodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue originating in the liver is less common. CASE PRESENTATION We described the clinical presentation, immunohistochemistry, and immunophenotypes of this lymphoma, which was misdiagnosed with tiny hepatic carcinoma in a 44-year-old woman with hepatitis C; the patient underwent left lateral sectionectomy. The...

BACKGROUND Lactoferrin (Lf), an iron-binding protein present in mammalian secretions, plays important roles in cancer prevention by inducing apoptosis. MATERIALS AND METHODS PC-14 lung adenocarcinoma cells were exposed to bovine Lf (bLf) protein and the expression of caspase-3 and apoptosis protease-activating factor-1 (APAF-1) was assessed. To investigate the molecular mechanism of apoptosis...

Acute lymphoblastic leukemia is predominantly found in children. It is a neoplasm of precursor cells or lymphoblasts committed to either a B- or T-cell lineage. The immature cells in B-acute lymphoblastic leukemia/lymphoma can be small or medium sized with scant or moderate cytoplasm and typically express B-cell markers such as CD19, cytoplasmic CD79a, and TdT without surface light chains. Thes...

A large mass from the right forelimb of a five-year-old, male, Maltese dog, was resected surgically and examined histopathologically. Grossly, the 4 × 6 cm mass was well-demarcated and firm. Microscopically, the mass was characterised by neoplastic mononuclear cells with large round hyperchromatic nuclei and scant cytoplasm. The neoplastic tumour cells were separated by thick or thin collagen s...

Introduction Identification and purification of mesenchymal stem cells (MSCs) expanded in culture for therapeutic use is crucial improved yield optimal results. Fibroblasts are the most common cell type connective tissue commonly found as contaminants MSC cultures, affecting potentially causing tumor formation after transplantation. In current study, we wished to identify surface markers that c...

CD19-directed treatment in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) frequently leads to the downmodulation of targeted antigens. As multicolour flow cytometry (MFC) application for minimal/measurable residual disease (MRD) assessment BCP-ALL is based on compartment study, CD19 loss could hamper MFC-MRD monitoring after blinatumomab or chimeric antigen receptor T-cell (CAR-T) the...

Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by neutrophil-rich nodules, abscesses or tunnels (sinus tracts). Tunnels, unique to HS, are deep dermal cavities lined with squamous epithelium that immunologically active, contributing pathology. The role of in driving ongoing poorly understood. We used the GeoMX Digital Spatial Profiler analyze a moderate (Hurley stag...

B cell tolerance can be maintained by functional inactivation, or anergy, wherein B cell Ag receptors (BCR) remain capable of binding Ag, but are unable to transduce signals. Although the molecular mechanisms underlying this unresponsiveness are unknown, some models of B cell anergy are characterized by disruption of proximal BCR signaling events, and by destabilization of the BCR complex. Rece...

Nodular lymphocyte predominant Hodgkin lymphoma appears in 5% of lymphoma. Because major biological and clinical differences with classical close relationship to T-cell/histiocyte-rich large B-cell lymphoma, lately the term nodular is accepted. The presence cells preserved phenotype a lack CD30 prerequisite for diagnosis Lymphocyte are typically embedded nodules B lymphocytes (growth patterns A...

Introduction: Acute Leukemia with Mixed Lineage phenotype (MLL) is leukemia that consists of cells characterized by mixed lineage markers, both from myeloid and lymphoid cells. The incidence this only 2-5% all acute leukemias considered to have a poor prognosis.Case Presentation: A seven-year-old girl was diagnosed MLL. results immunophenotyping showed two blast populations the expressions CD33...